{"id":"W2161287613","doi":"10.1158/0008-5472.can-11-4199","title":"Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Ligue Contre le Cancer","keywords":"Temozolomide; Integrin; Glioma; Cancer research; Integrin alpha M; Medicine; Biology; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066959,0.0002079882,0.0001375145,0.0001402202,0.0001329989,0.0003094005,0.0001182095,0.0002039004,0.0006448667],"category_scores_gemma":[0.00009408666,0.00009156854,0.0001555387,0.00010866,0.0001415985,0.0001572342,0.00009138379,0.0002805542,0.0001381189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517689,"about_ca_system_score_gemma":0.0001077314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008160667,"about_ca_topic_score_gemma":0.001074522,"domain_scores_codex":[0.9999301,0.00001755102,0.000005533384,0.000008605909,0.00001612924,0.00002215003],"domain_scores_gemma":[0.9999707,0.000005525888,0.0000100597,0.000003871963,0.000003319157,0.000006630598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342214,0.00002276843,0.0008446966,0.00002661927,0.000007411548,0.00006738764,0.00001645428,0.0000570807,0.9962175,0.0001324538,0.00004174767,0.002431718],"study_design_scores_gemma":[0.00004109753,0.0006736512,0.03524662,0.00001209472,0.00008693836,0.0009200342,0.00007951215,0.00197529,0.9565803,0.0001538808,0.004226248,0.000004288894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960349,0.002405952,0.0008254005,0.00007825917,0.000006358844,0.000006151904,0.00002598037,0.00001847035,0.0005985857],"genre_scores_gemma":[0.9987823,0.0005942917,0.0002347276,0.00001386642,0.000001780284,0.000003368351,0.00003885367,0.00000202197,0.0003287726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008160667,"threshold_uncertainty_score":0.002157271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808890190628758,"score_gpt":0.3906281873462974,"score_spread":0.3425392854400098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}