{"id":"W2161308975","doi":"10.4049/jimmunol.169.8.4467","title":"Synergistic Engagement of an Ineffective Endogenous Anti-Tumor Immune Response and Induction of IFN-γ and Fas-Ligand-Dependent Tumor Eradication by Combined Administration of IL-18 and IL-2","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute; National Institutes of Health","keywords":"Endogeny; Immune system; Fas ligand; Cytokine; In vivo; Immunology; Cancer research; CD8; Biology; Ex vivo; Apoptosis; Endocrinology; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002838861,0.0005950534,0.0005276974,0.000188647,0.00008923439,0.0003670828,0.0001864493,0.0002346433,0.001045173],"category_scores_gemma":[0.0001528502,0.0001324895,0.0002832127,0.0001107784,0.0002581073,0.000265922,0.0002659368,0.0007190008,0.0002760097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108664,"about_ca_system_score_gemma":0.0002713887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001120212,"about_ca_topic_score_gemma":0.000359648,"domain_scores_codex":[0.9996798,0.00008714738,0.00002537479,0.00004533823,0.00007917406,0.00008321802],"domain_scores_gemma":[0.9998116,0.00003743304,0.00006169877,0.0000324782,0.00001295531,0.0000437822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002866357,0.0001083399,0.000233347,0.00005166516,0.00001359348,0.00007163228,0.00001209605,0.0001417626,0.9956633,0.00007327276,0.00002986602,0.003314384],"study_design_scores_gemma":[0.00007197235,0.001806761,0.0009631464,0.000006736034,0.00003321893,0.0004726235,0.00001234043,0.0004942873,0.9939775,0.00003995647,0.002118135,0.00000341459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886531,0.003105129,0.006389402,0.0001200591,0.00005889817,0.00008469455,0.0001038168,0.0001246984,0.00136015],"genre_scores_gemma":[0.9936497,0.0009467699,0.00414654,0.00005506011,0.00003773627,0.0000785962,0.000125949,0.00001763513,0.0009420797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045173,"threshold_uncertainty_score":0.003496408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298228498379285,"score_gpt":0.2299495960520918,"score_spread":0.216967311068299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}