{"id":"W2161336797","doi":"10.1158/1535-7163.mct-11-0421","title":"Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Ontario Institute for Cancer Research","keywords":"Digitoxin; Kinase; Pharmacology; Cancer cell; Biology; Signal transduction; Kinome; Cancer; Cancer research; Chemistry; Biochemistry; Heart failure; Internal medicine; Medicine; Digoxin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009301324,0.0002611022,0.0002192641,0.0001935831,0.0001628092,0.000255218,0.00008693089,0.0001768444,0.0007218328],"category_scores_gemma":[0.00007906578,0.0000711313,0.0002263577,0.000229767,0.0001157535,0.0001698309,0.0001691262,0.0002573642,0.0002079957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716333,"about_ca_system_score_gemma":0.0001464045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002483425,"about_ca_topic_score_gemma":0.0004786774,"domain_scores_codex":[0.9998976,0.00001220449,0.000008821906,0.00002413462,0.0000382682,0.0000190124],"domain_scores_gemma":[0.9999473,0.000009952714,0.00002204744,0.00000526434,0.000008654815,0.000006717794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106604,0.00001199974,0.0007232885,0.00004652908,0.000005993253,0.00005328398,0.00001189417,0.0001244346,0.996594,0.00006897267,0.00002188454,0.002227169],"study_design_scores_gemma":[0.0000171806,0.000250711,0.0248254,0.000006841808,0.00002452886,0.0003151405,0.00005263865,0.002702294,0.9703371,0.0001266012,0.001335471,0.000006011308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911637,0.002518779,0.003923045,0.0001079938,0.00001766195,0.00003471013,0.0004533984,0.00007506337,0.001705707],"genre_scores_gemma":[0.9948702,0.00160626,0.001929952,0.00007121389,0.000004978113,0.00003235999,0.0004726579,0.000004721452,0.001007673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007218328,"threshold_uncertainty_score":0.002414823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03812928380603275,"score_gpt":0.2710847490789784,"score_spread":0.2329554652729457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}