{"id":"W2161350677","doi":"10.1016/j.cell.2013.07.007","title":"Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Cancer Research UK; Wellcome Trust","keywords":"Biology; Transcription factor; Genetics; Cooperativity; Evolutionary biology; Genome; Gene; Binding site; Population; Regulatory sequence; DNA binding site; Computational biology; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00052118,0.0001904177,0.0004834169,0.001133457,0.0003874802,0.0004648181,0.0006028825,0.0004047478,0.0006274502],"category_scores_gemma":[0.0009566662,0.0004157416,0.0002521398,0.0004887566,0.0008846038,0.0002518554,0.0006969699,0.0003678158,0.0001698175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004059817,"about_ca_system_score_gemma":0.0001278731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010448,"about_ca_topic_score_gemma":0.002646595,"domain_scores_codex":[0.9994403,0.00009317796,0.0000275381,0.0002712001,0.0001071026,0.00006067648],"domain_scores_gemma":[0.9993155,0.0002484004,0.000175875,0.000113385,0.0000577667,0.00008905981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730617,0.00002366135,0.05625881,0.00004345162,0.00009611045,0.000158594,0.000404727,0.0008209113,0.9364032,0.0006374728,0.00002221858,0.004957811],"study_design_scores_gemma":[0.00002945161,0.0001780756,0.9509519,0.00001200613,0.00009798496,0.00130966,0.0002620796,0.004935019,0.03977909,0.001322684,0.00108255,0.00003967038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984385,0.0001824469,0.0009826212,0.000009182229,8.067014e-7,0.000002970261,0.00002282576,0.00001368504,0.0003469744],"genre_scores_gemma":[0.9989821,0.00006623635,0.0007023184,0.00002105928,0.000003075224,0.000005678838,0.00006939247,0.00001233676,0.0001378199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133457,"threshold_uncertainty_score":0.002945602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005318652444086791,"score_gpt":0.1856865917736628,"score_spread":0.180367939329576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}