{"id":"W2161377277","doi":"10.1016/s0140-6736(15)00465-1","title":"Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study","year":2015,"lang":"en","type":"article","venue":"The Lancet","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":778,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Montreal Heart Institute; Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Health and Medical Research Council; Karolinska Institutet; Vetenskapsrådet; Agency for Healthcare Research and Quality; Crohn's and Colitis UK; Ministero della Salute; Diabetes UK; Fonds Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Fédération Wallonie-Bruxelles; Fonds De La Recherche Scientifique - FNRS; University of Oxford; Universitetssjukhuset Örebro; King's College London; European Commission; University of Pittsburgh; Cedars-Sinai Medical Center; University of Manchester; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Svenska Läkaresällskapet; Waalse Gewest; National Institute for Health and Care Research; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Örebro Universitet; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Ulcerative colitis; Phenotype; Crohn's disease; Medicine; Disease; Crohn disease; Colitis; Genetic association; Genetics; Gastroenterology; Internal medicine; Genotype; Biology; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001545928,0.0006375366,0.0005520928,0.001046014,0.0008821957,0.0006599765,0.0005513534,0.000681576,0.002485218],"category_scores_gemma":[0.004501435,0.0003928354,0.0006367672,0.002164907,0.0006066669,0.0002442551,0.0007364237,0.0006553127,0.0002736841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004610063,"about_ca_system_score_gemma":0.0005936711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009447381,"about_ca_topic_score_gemma":0.009647834,"domain_scores_codex":[0.9984713,0.0005855248,0.0001214552,0.0004070956,0.0002568607,0.000157761],"domain_scores_gemma":[0.9972073,0.001096047,0.0007925247,0.0002951786,0.0001777297,0.0004310929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004280024,0.00005876921,0.9957741,0.00001344406,0.000293871,0.0005510607,0.0001394351,0.0001182015,0.0009632604,0.0000529847,0.0001141121,0.001492727],"study_design_scores_gemma":[0.00007360886,0.0001574114,0.9979703,0.000007621895,0.0001737459,0.0008655219,0.00007516826,0.0003434033,0.0001022263,0.00004345081,0.0001819004,0.000005661574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999244,0.0001241504,0.0001866673,0.00003767898,0.00000286595,0.00001350985,0.0002181966,0.00000276339,0.0001701957],"genre_scores_gemma":[0.9990728,0.00007139955,0.0004016932,0.00002207806,0.00001437905,0.00001510372,0.0002781892,0.000003317967,0.0001209416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009447381,"threshold_uncertainty_score":0.01878482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013248843662682,"score_gpt":0.2754589860326019,"score_spread":0.2553264975959751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}