{"id":"W2161377277","doi":"10.1016/s0140-6736(15)00465-1","title":"Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study","year":2015,"lang":"en","type":"article","venue":"The Lancet","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":778,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Montreal Heart Institute; Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Health and Medical Research Council; Karolinska Institutet; Vetenskapsrådet; Agency for Healthcare Research and Quality; Crohn's and Colitis UK; Ministero della Salute; Diabetes UK; Fonds Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Fédération Wallonie-Bruxelles; Fonds De La Recherche Scientifique - FNRS; University of Oxford; Universitetssjukhuset Örebro; King's College London; European Commission; University of Pittsburgh; Cedars-Sinai Medical Center; University of Manchester; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Svenska Läkaresällskapet; Waalse Gewest; National Institute for Health and Care Research; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Örebro Universitet; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Ulcerative colitis; Phenotype; Crohn's disease; Medicine; Disease; Crohn disease; Colitis; Genetic association; Genetics; Gastroenterology; Internal medicine; Genotype; Biology; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002383021,0.0000761806,0.0001306303,0.00001012116,0.00003833757,0.00001746795,0.0001179115,0.00003345236,0.000004080977],"category_scores_gemma":[0.0002630125,0.00005889694,0.00002017162,0.00003323429,0.00004348124,0.000002849445,0.0000734132,0.00003448488,0.000004134532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000174108,"about_ca_system_score_gemma":0.00007802348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001982852,"about_ca_topic_score_gemma":0.0002860734,"domain_scores_codex":[0.9993063,0.0001921681,0.0001189505,0.000133779,0.0001178454,0.0001309296],"domain_scores_gemma":[0.999428,0.00001076446,0.00009618635,0.0002717806,0.0001081199,0.00008513422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001641925,0.00009357223,0.9937406,0.00002323901,0.00006519376,0.00007029795,0.0007891275,0.0000207385,0.0005315883,0.00001126052,0.002507111,0.0005053667],"study_design_scores_gemma":[0.001251805,0.00009228078,0.9974694,0.000007123504,0.00004935569,6.882134e-7,0.0002445768,0.00008655428,0.0002094859,0.0001452128,0.0003689079,0.00007460911],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991728,0.0001311966,0.000009569465,0.00005883877,0.00004817146,0.0003242102,0.000065166,0.000006814839,0.0001832363],"genre_scores_gemma":[0.9992606,0.00002007991,0.00005196554,0.0001533491,0.0002536152,0.00003366272,0.00001079047,0.000009435721,0.0002064969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003728821,"threshold_uncertainty_score":0.2401747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013248843662682,"score_gpt":0.2754589860326019,"score_spread":0.2553264975959751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}