{"id":"W2161386375","doi":"10.1002/1097-4652(200010)185:1<80::aid-jcp7>3.0.co;2-w","title":"Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia","year":2000,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council Canada","keywords":"Heme oxygenase; Downregulation and upregulation; Superoxide dismutase; Superoxide; Oxidative stress; Heme; Mitochondrion; Biology; Molecular biology; Transfection; Intracellular; Cell biology; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004853061,0.0001500629,0.0003513956,0.0001069579,0.00001804059,0.00000307525,0.0003011279,0.000163948,0.0001003505],"category_scores_gemma":[0.0000365489,0.0001097032,0.0001688673,0.0001246802,0.0001024333,0.00001254909,0.00003658146,0.00018159,0.000001993118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001400805,"about_ca_system_score_gemma":0.00005960819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002037092,"about_ca_topic_score_gemma":0.00002023829,"domain_scores_codex":[0.9984015,0.0004176894,0.0006063318,0.0001828612,0.0001884499,0.0002032184],"domain_scores_gemma":[0.9991982,0.00003021074,0.0003342855,0.0003026639,0.00008657621,0.0000480465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000644802,0.0002689425,0.0002575527,0.00002109385,0.00002402801,0.00001033878,0.0003438995,0.0007628805,0.9966938,0.00001732003,0.0000519092,0.0009034078],"study_design_scores_gemma":[0.0009696724,0.0004597162,0.04251087,0.00003855929,0.0000117461,0.00001893522,0.000437806,0.00006903747,0.9545964,0.000296731,0.0004978717,0.00009264341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978245,0.001753632,0.00005679222,0.00006096103,0.00002803217,0.0001223183,0.00001135686,0.000001086986,0.0001413069],"genre_scores_gemma":[0.9989233,0.0003810088,0.0004364731,0.00003378325,0.0001273489,0.00000522688,0.00003308868,0.00001403108,0.0000457576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04225331,"threshold_uncertainty_score":0.4473567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006505057436141736,"score_gpt":0.2162240202961605,"score_spread":0.2097189628600188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}