{"id":"W2161408324","doi":"10.1073/pnas.1302891110","title":"Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Vetenskapsrådet; Karolinska Institutet; Cancerfonden; European Commission","keywords":"Platelet-derived growth factor receptor; Tyrosine phosphorylation; Protein tyrosine phosphatase; Cell biology; Phosphorylation; Auranofin; Signal transduction; Receptor tyrosine kinase; Biochemistry; Thioredoxin; Chemistry; Tyrosine kinase; Tyrosine; Biology; Receptor; Growth factor; Oxidative stress; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007871204,0.0001081066,0.0001418475,0.00005187699,0.0001630457,0.00002248238,0.0006572634,0.00009826257,0.000007371639],"category_scores_gemma":[0.0007113083,0.00006405316,0.00006965188,0.0004463938,0.0005621475,0.00005300631,0.0001420579,0.00009550832,8.954417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002609171,"about_ca_system_score_gemma":0.00003765772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004343291,"about_ca_topic_score_gemma":2.807524e-8,"domain_scores_codex":[0.9986792,0.00001653716,0.0003192732,0.000235977,0.0006124906,0.0001365823],"domain_scores_gemma":[0.9987279,0.00006386524,0.0006000762,0.00001707195,0.0005670207,0.00002411933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002989621,0.00002743003,0.0003822634,0.00006049894,0.00002205126,2.953644e-10,0.00003657149,0.00009338199,0.9902105,0.00617261,0.002848515,0.0001162578],"study_design_scores_gemma":[0.0001845242,0.00008106037,0.002111573,0.0001127445,0.000008682873,0.000001408816,0.0001923469,0.0004219552,0.9946698,0.002069273,0.00007422899,0.00007242424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967992,0.001031356,0.000015741,0.001320416,0.00001432449,0.0004523557,0.00004842288,0.00000698589,0.0003112488],"genre_scores_gemma":[0.9981811,0.00002130864,0.001513756,0.0001036632,0.00006304652,0.00004908671,0.000002863078,0.000005980968,0.00005919649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004459254,"threshold_uncertainty_score":0.2612012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485218111209309,"score_gpt":0.2539054542590197,"score_spread":0.2390532731469266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}