{"id":"W2161408324","doi":"10.1073/pnas.1302891110","title":"Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Vetenskapsrådet; Karolinska Institutet; Cancerfonden; European Commission","keywords":"Platelet-derived growth factor receptor; Tyrosine phosphorylation; Protein tyrosine phosphatase; Cell biology; Phosphorylation; Auranofin; Signal transduction; Receptor tyrosine kinase; Biochemistry; Thioredoxin; Chemistry; Tyrosine kinase; Tyrosine; Biology; Receptor; Growth factor; Oxidative stress; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430397,0.000212003,0.0001863613,0.00009854946,0.0000749395,0.0001921375,0.00009718406,0.0001666534,0.000710813],"category_scores_gemma":[0.00007725279,0.0001007394,0.0001981986,0.00008588354,0.0001257848,0.0001400056,0.0001177175,0.0004753617,0.0001189512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355544,"about_ca_system_score_gemma":0.00008262423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003056376,"about_ca_topic_score_gemma":0.0003149855,"domain_scores_codex":[0.9998932,0.00002124235,0.000007327568,0.00002121987,0.0000201779,0.00003695898],"domain_scores_gemma":[0.9999579,0.000005486461,0.00001491427,0.000004515842,0.000005407365,0.0000117962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152503,0.0000162371,0.00008986279,0.0000184202,0.000004477757,0.00001973244,0.000008069954,0.00001828882,0.9991677,0.00002463958,0.000009334361,0.0005078419],"study_design_scores_gemma":[0.00001720182,0.00040632,0.005741597,0.000004473929,0.0000188321,0.000160024,0.00002563945,0.0005924072,0.9922957,0.00002750929,0.0007074773,0.000002795658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975127,0.001168335,0.0007639771,0.0000349316,0.00001554673,0.000008935928,0.00005624396,0.00001589966,0.0004233325],"genre_scores_gemma":[0.9979331,0.0007323831,0.0004485077,0.00001886072,0.000005039466,0.00001092564,0.0001069237,0.000004123143,0.0007401376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000710813,"threshold_uncertainty_score":0.002377927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485218111209309,"score_gpt":0.2539054542590197,"score_spread":0.2390532731469266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}