{"id":"W2161479848","doi":"10.1200/jco.2014.59.7401","title":"Germline <i>BRCA</i> Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Cancer Society Research Institute","keywords":"Medicine; Oncology; Family history; Pancreatic cancer; Genetic testing; Internal medicine; BRCA mutation; Cancer; Cohort; Sanger sequencing; Germline mutation; Breast cancer; Genetic counseling; Ovarian cancer; Adenocarcinoma; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004469595,0.0002817771,0.0003976348,0.0007818443,0.0008534632,0.0007635516,0.0004426651,0.0004698137,0.001644543],"category_scores_gemma":[0.002132872,0.000409536,0.0002921269,0.0006310206,0.0003865944,0.0003879187,0.0003993269,0.0005649757,0.0002912417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266259,"about_ca_system_score_gemma":0.0003125604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004155839,"about_ca_topic_score_gemma":0.00430485,"domain_scores_codex":[0.9994557,0.0001282129,0.00004484004,0.0002039265,0.0001060388,0.00006122744],"domain_scores_gemma":[0.9989065,0.00027127,0.0003625261,0.00009181799,0.0001287581,0.0002391827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005801228,0.00002894566,0.9986765,0.000003836998,0.00001919553,0.0002407233,0.00005036066,0.0000133334,0.0003173865,0.00000529062,0.00007588237,0.0005105791],"study_design_scores_gemma":[0.00002253471,0.0001416532,0.9960814,0.000006697185,0.00003604572,0.002988477,0.0002434828,0.000174788,0.0001065025,0.00001455827,0.0001794147,0.000004453895],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996371,0.00007274615,0.000038539,0.00002210446,0.000003486471,0.000006611744,0.00007357952,0.000003074758,0.000142708],"genre_scores_gemma":[0.9996498,0.00004754844,0.00005586538,0.00003297151,0.00001062656,0.000007197291,0.0001445041,0.000001625452,0.00004987893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004155839,"threshold_uncertainty_score":0.00826329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176631675558528,"score_gpt":0.46802045403138,"score_spread":0.3503572864755273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}