{"id":"W2161491285","doi":"10.1073/pnas.1106277108","title":"Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research","keywords":"Nucleus accumbens; Nicotine; Dopamine; Addiction; Nicotinic agonist; Conditioned place preference; Striatum; Medium spiny neuron; Pharmacology; Protein kinase C; Neuroscience; Cholinergic; Chemistry; Endocrinology; Internal medicine; Biology; Receptor; Medicine; Kinase; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007784817,0.0001988402,0.0001650631,0.0001636603,0.0001005583,0.0002570765,0.0001597766,0.0002101598,0.0006953508],"category_scores_gemma":[0.0001081983,0.0001158023,0.0001230627,0.00006773859,0.0002102204,0.0001686285,0.0001668958,0.0003509041,0.0001607916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004088969,"about_ca_system_score_gemma":0.0001639622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049789,"about_ca_topic_score_gemma":0.002377258,"domain_scores_codex":[0.9999403,0.000009436284,0.000004351539,0.00001165741,0.00001573426,0.0000184788],"domain_scores_gemma":[0.9999441,0.000004401424,0.00001833374,0.000004505783,0.000008031185,0.00002065631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003344038,0.00003774362,0.001187309,0.0000170418,0.000009466776,0.00006048544,0.000008198767,0.00007146657,0.9961719,0.00008543288,0.00003105392,0.00198548],"study_design_scores_gemma":[0.0001101697,0.0005353462,0.2117545,0.00002297224,0.00007886295,0.0008188762,0.0001257873,0.004968609,0.779372,0.000634902,0.00156116,0.00001678359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983131,0.0005407898,0.0003971096,0.00009265698,0.0000103705,0.000003700653,0.00005118498,0.00001267057,0.0005784513],"genre_scores_gemma":[0.997638,0.0006055858,0.0003322521,0.00003339199,0.000003359842,0.000006406616,0.00007031539,0.00000666149,0.001304004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049789,"threshold_uncertainty_score":0.002966821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783999513270611,"score_gpt":0.2906637925620966,"score_spread":0.2328237974293905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}