{"id":"W2161531510","doi":"10.1021/es3019258","title":"Transcriptional Responses of the Brain–Gonad–Liver Axis of Fathead Minnows Exposed to Untreated and Ozone-Treated Oil Sands Process-Affected Water","year":2012,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Biology; Gonad; Estrogen; Toxicity; Hormone; Endocrine system; Estrogen receptor; Cyprinidae; Pimephales promelas; Endocrine disruptor; Sexual differentiation; Physiology; Transcriptome; Testosterone (patch); Fish <Actinopterygii>; Internal medicine; Andrology; Endocrinology; Minnow; Gene; Gene expression; Genetics; Fishery; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004447333,0.0002204365,0.0002033756,0.0001798197,0.0001690575,0.0001941611,0.0000827234,0.0001958052,0.001355613],"category_scores_gemma":[0.00008585709,0.0001484241,0.0002418518,0.0001170263,0.0002118547,0.0001225529,0.0001585706,0.0002723514,0.0001119074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002727362,"about_ca_system_score_gemma":0.0002359441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003586981,"about_ca_topic_score_gemma":0.006833974,"domain_scores_codex":[0.9999286,0.00000442494,0.000003982338,0.00003012448,0.00001136454,0.00002158142],"domain_scores_gemma":[0.9999472,0.000004321108,0.00001622643,0.000002748503,0.00001299259,0.0000165442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009223711,0.00004647761,0.01079256,0.00004001434,0.00001786081,0.00005413646,0.0001246612,0.00002886716,0.9864331,0.0000276366,0.00004120028,0.001471138],"study_design_scores_gemma":[0.00004352151,0.00170511,0.7265151,0.00001273181,0.00009173768,0.0002007346,0.0009645457,0.0005430907,0.2684378,0.00008662247,0.001380625,0.00001828244],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991548,0.000140907,0.0001113877,0.00002080574,0.000007882386,0.000005945478,0.0003329842,0.000004230992,0.0002210226],"genre_scores_gemma":[0.9957908,0.0002406354,0.0003645474,0.00007095849,0.000005450134,0.00005614259,0.0008705434,0.000004879016,0.002596141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003586981,"threshold_uncertainty_score":0.007132173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008832520107865845,"score_gpt":0.2328535094245739,"score_spread":0.2240209893167081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}