{"id":"W2161531510","doi":"10.1021/es3019258","title":"Transcriptional Responses of the Brain–Gonad–Liver Axis of Fathead Minnows Exposed to Untreated and Ozone-Treated Oil Sands Process-Affected Water","year":2012,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Biology; Gonad; Estrogen; Toxicity; Hormone; Endocrine system; Estrogen receptor; Cyprinidae; Pimephales promelas; Endocrine disruptor; Sexual differentiation; Physiology; Transcriptome; Testosterone (patch); Fish <Actinopterygii>; Internal medicine; Andrology; Endocrinology; Minnow; Gene; Gene expression; Genetics; Fishery; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128981,0.000130683,0.0001460761,0.0001532509,0.0001261673,0.000003610415,0.000285265,0.0001507855,0.00007279412],"category_scores_gemma":[0.0001835895,0.00007886112,0.0000351592,0.0003037348,0.002667267,0.00001711831,0.0001417072,0.00006573796,0.000005378416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002833078,"about_ca_system_score_gemma":0.0000267477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007588526,"about_ca_topic_score_gemma":0.0000045725,"domain_scores_codex":[0.9989774,0.00006054686,0.0001773277,0.0003244444,0.0001528358,0.0003074654],"domain_scores_gemma":[0.9995087,0.00001174173,0.00006679774,0.0003307035,0.00002126675,0.00006081249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395392,0.0001300276,0.0833169,0.000004732535,0.0000160178,2.242821e-7,0.0003081462,0.000002057399,0.9141302,0.00005178951,0.00002374231,0.001876664],"study_design_scores_gemma":[0.0002348493,0.0003487808,0.2681099,0.000005689802,0.000009025879,0.00002156483,0.0002236621,0.000001737292,0.7296193,0.00002272188,0.001328501,0.00007429368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998312,0.0004859047,0.00002707484,0.0007628642,0.00005018793,0.0001540676,0.00003188235,0.000009447212,0.0001665768],"genre_scores_gemma":[0.9989987,0.00004998611,0.0001126776,0.00008829256,0.00001858558,0.00001745412,0.0000129355,0.000006757891,0.0006945804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.184793,"threshold_uncertainty_score":0.9827656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008832520107865845,"score_gpt":0.2328535094245739,"score_spread":0.2240209893167081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}