{"id":"W2161560609","doi":"10.1139/o07-069","title":"Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.","year":2007,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":393,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Rad50; Nijmegen breakage syndrome; Biology; Chromatin; DNA repair; Cell biology; DNA damage; DNA; G2-M DNA damage checkpoint; Genetics; DNA-binding protein; Cell cycle checkpoint; Ataxia-telangiectasia; Cell cycle; Cancer; Transcription factor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000801514,0.0007189388,0.0006700726,0.001189681,0.000984556,0.003088523,0.0005472463,0.0008644776,0.03173434],"category_scores_gemma":[0.0008800338,0.0004334292,0.0003543265,0.0009946058,0.000682419,0.001795927,0.001423184,0.0006815305,0.02464234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008035352,"about_ca_system_score_gemma":0.001658063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000516657,"about_ca_topic_score_gemma":0.0007422384,"domain_scores_codex":[0.9993495,0.00006437471,0.00004357136,0.0001734855,0.0002932694,0.00007567125],"domain_scores_gemma":[0.9994235,0.00003647421,0.0001359956,0.00004423969,0.0001920274,0.0001678206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005483953,0.0001131309,0.004264491,0.00258324,0.000134761,0.0010771,0.0002501814,0.0005879814,0.4569603,0.01070963,0.1075316,0.4152391],"study_design_scores_gemma":[0.00001353848,0.00009977568,0.005417555,0.0001040227,0.00002386698,0.0007365763,0.0001511235,0.000291874,0.07395221,0.0008826823,0.9182972,0.00002960427],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.196407,0.4278237,0.06366618,0.01899481,0.05494146,0.001306925,0.009131728,0.006698631,0.2210295],"genre_scores_gemma":[0.3816307,0.1440349,0.02674175,0.00174559,0.007227882,0.0002275408,0.01425333,0.001031715,0.4231065],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03173434,"threshold_uncertainty_score":0.106162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03441432956791329,"score_gpt":0.3014059242214445,"score_spread":0.2669915946535312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}