{"id":"W2161588299","doi":"10.1186/1756-8935-4-7","title":"Extensive epigenetic reprogramming in human somatic tissues between fetus and adult","year":2011,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"National Institutes of Health; Michael Smith Health Research BC; Canadian Institute for Advanced Research","keywords":"Reprogramming; Biology; Somatic cell; Epigenetics; Human genetics; Fetus; Epigenesis; Cell biology; Genetics; DNA methylation; Pregnancy; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002794628,0.0003245017,0.0003783283,0.0001158192,0.0001393809,0.00004772351,0.0002830382,0.0002270021,0.00004644525],"category_scores_gemma":[0.0001802186,0.0003433826,0.00008281828,0.0001574623,0.0001611104,0.000004993795,0.0002965468,0.0001392355,0.00002056277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001705245,"about_ca_system_score_gemma":0.00003716514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000289031,"about_ca_topic_score_gemma":0.0001287854,"domain_scores_codex":[0.9977896,0.0001192169,0.0006494016,0.0006829296,0.0001881052,0.0005707612],"domain_scores_gemma":[0.9988294,0.00002286084,0.0002103955,0.0006465022,0.0001139516,0.0001768608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006263173,0.0001422517,0.4488494,0.0001743496,0.0001056187,0.00002391949,0.002256631,0.00001781289,0.4954908,0.000096298,0.00007470002,0.0527619],"study_design_scores_gemma":[0.0006891534,0.0006088474,0.6971192,0.000106734,0.00004599366,0.00003843885,0.0006282174,0.00006313877,0.2988003,0.0007402275,0.0006850259,0.0004746178],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994971,0.002078711,0.001075009,0.00003461106,0.00007478537,0.0004258724,0.000006009437,0.00002893986,0.001305099],"genre_scores_gemma":[0.9778134,0.0003124793,0.0212358,0.00006150699,0.0001646668,0.00004795938,0.00005233157,0.00006325564,0.0002485576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2482698,"threshold_uncertainty_score":0.9999018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308012366844991,"score_gpt":0.2659722796408841,"score_spread":0.2428921559724342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}