{"id":"W2161597997","doi":"10.18433/j3tp4t","title":"Preparation of Chitosan-Plasmid DNA Nanoparticles Encoding Interleukin-12 and their Expression in CT-26 Colon Carcinoma Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transfection; Dispersity; Chitosan; Zeta potential; Cytotoxicity; Coacervate; Gene delivery; Molecular biology; MTT assay; Chemistry; Naked DNA; Nuclear chemistry; Particle size; Nanoparticle; Materials science; In vitro; Nanotechnology; Biology; Chromatography; Biochemistry; Polymer chemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004427283,0.0001240844,0.0001775592,0.0001013207,0.00006258643,0.00002385407,0.0002873069,0.00002767163,0.00003598799],"category_scores_gemma":[0.00003392348,0.00008743027,0.00007338781,0.0001116855,0.0002770537,0.00005226182,0.000107232,0.0001277793,0.000001097977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007524599,"about_ca_system_score_gemma":0.00008516293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001367781,"about_ca_topic_score_gemma":0.000008804324,"domain_scores_codex":[0.9988525,0.0001219945,0.0004405031,0.0001982029,0.0001711121,0.0002156882],"domain_scores_gemma":[0.999495,0.00003572155,0.000231829,0.0000687244,0.00004234673,0.0001263354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004670956,0.0002524805,0.01789417,0.00001731443,0.00001234366,0.00001061312,0.0007427701,0.00001711499,0.9764686,0.000005716561,0.00008342373,0.004028349],"study_design_scores_gemma":[0.001303002,0.0005717715,0.001104381,0.00005207883,0.00001664789,0.00006814536,0.0004080793,0.0009275214,0.9943362,0.00003329188,0.001078827,0.0001000247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977297,0.001215354,0.00005761482,0.00006925146,0.0002586438,0.00008959896,0.000003160841,0.00000278718,0.0005739238],"genre_scores_gemma":[0.9986973,0.0007963381,0.0002746228,0.0001261543,0.00009156172,0.000002566803,4.578114e-7,0.000005765391,0.000005259151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01786762,"threshold_uncertainty_score":0.3565303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0647305068738895,"score_gpt":0.3559498986387989,"score_spread":0.2912193917649095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}