{"id":"W2161597997","doi":"10.18433/j3tp4t","title":"Preparation of Chitosan-Plasmid DNA Nanoparticles Encoding Interleukin-12 and their Expression in CT-26 Colon Carcinoma Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transfection; Dispersity; Chitosan; Zeta potential; Cytotoxicity; Coacervate; Gene delivery; Molecular biology; MTT assay; Chemistry; Naked DNA; Nuclear chemistry; Particle size; Nanoparticle; Materials science; In vitro; Nanotechnology; Biology; Chromatography; Biochemistry; Polymer chemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635037,0.0003135638,0.0002117686,0.0001809354,0.0001157123,0.0001580831,0.0001677453,0.0002508555,0.0005483219],"category_scores_gemma":[0.0001442291,0.0001142605,0.000231614,0.000257457,0.0001549828,0.000139906,0.0001268167,0.0003032294,0.0002602929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435161,"about_ca_system_score_gemma":0.0002058806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001196308,"about_ca_topic_score_gemma":0.001793514,"domain_scores_codex":[0.9998882,0.00001215724,0.00001229952,0.00003172773,0.00004233315,0.00001334415],"domain_scores_gemma":[0.9999293,0.000009689774,0.00002028753,0.000007411857,0.00002322377,0.0000100396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004780542,0.00001230118,0.00007747,0.00005664136,0.000003598763,0.000036199,0.00001229371,0.0001738583,0.9982786,0.00004619676,0.00002896176,0.001225973],"study_design_scores_gemma":[0.00001688162,0.0002122487,0.0006966593,0.000006040749,0.00001385346,0.00009996066,0.000007021205,0.0008782406,0.9960402,0.00001354915,0.002010404,0.000004889947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972221,0.002313273,0.02148859,0.0001239196,0.00007276113,0.0002810479,0.0006278335,0.0001783627,0.002693257],"genre_scores_gemma":[0.967139,0.001325952,0.02489819,0.00004442091,0.0000122038,0.0002503658,0.0008838295,0.00003686379,0.005409153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196308,"threshold_uncertainty_score":0.002492428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0647305068738895,"score_gpt":0.3559498986387989,"score_spread":0.2912193917649095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}