{"id":"W2161601725","doi":"10.2174/092986711796011265","title":"Novel Circular, Cyclic and Acyclic ψ(CH2O) Containing Peptide Inhibitors of SKI- 1/S1P: Synthesis, Kinetic and Biochemical Evaluations","year":2011,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cyclic peptide; Subtilisin; Chemistry; Peptide; Biochemistry; Amino acid; Furin; Kexin; Stereochemistry; Serine; Proprotein convertase; Peptide sequence; Peptide synthesis; Serine protease; Protease; Enzyme; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404856,0.0004452212,0.0002412427,0.0001958877,0.000111215,0.0001702389,0.0003748544,0.0002304814,0.002214157],"category_scores_gemma":[0.0001107738,0.0001234433,0.0002057516,0.0001622691,0.0001246286,0.0001815995,0.0001039179,0.000450878,0.0006537343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002536517,"about_ca_system_score_gemma":0.0002388747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877766,"about_ca_topic_score_gemma":0.0005560883,"domain_scores_codex":[0.9999343,0.000008044322,0.000006232981,0.00001225682,0.00001744156,0.0000217253],"domain_scores_gemma":[0.9999328,0.000009773184,0.00001867009,0.000003879408,0.00001023979,0.00002456317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009341319,0.0003423984,0.0001502796,0.0002650088,0.000023419,0.0002089496,0.00002771221,0.001257911,0.9785336,0.0004476514,0.0005170148,0.01729191],"study_design_scores_gemma":[0.0003356292,0.004281587,0.001012334,0.00001570522,0.00005514054,0.0005198961,0.00001369157,0.001745544,0.9777956,0.0000720164,0.01413106,0.00002194544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638884,0.01252182,0.0118676,0.0002287481,0.000173508,0.0006559505,0.001682388,0.0002326528,0.008748959],"genre_scores_gemma":[0.9691288,0.007168701,0.01458638,0.000137435,0.00005088562,0.0003499305,0.001781408,0.00003789159,0.006758451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002214157,"threshold_uncertainty_score":0.007407129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027884147655492,"score_gpt":0.2906119177606641,"score_spread":0.2503330762841092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}