{"id":"W2161601725","doi":"10.2174/092986711796011265","title":"Novel Circular, Cyclic and Acyclic ψ(CH2O) Containing Peptide Inhibitors of SKI- 1/S1P: Synthesis, Kinetic and Biochemical Evaluations","year":2011,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cyclic peptide; Subtilisin; Chemistry; Peptide; Biochemistry; Amino acid; Furin; Kexin; Stereochemistry; Serine; Proprotein convertase; Peptide sequence; Peptide synthesis; Serine protease; Protease; Enzyme; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003082246,0.0002715886,0.0003024575,0.00004216243,0.00007873433,0.00001257199,0.0001698699,0.0002175162,0.00006158516],"category_scores_gemma":[0.000631961,0.0002603372,0.00008894434,0.0000886839,0.0003295926,0.000008333598,0.0001753415,0.0002272901,0.000002376545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001863133,"about_ca_system_score_gemma":0.0001009037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002226322,"about_ca_topic_score_gemma":0.000001228684,"domain_scores_codex":[0.9984533,0.00003327672,0.0004138097,0.0005157245,0.0002817029,0.0003021838],"domain_scores_gemma":[0.9990325,0.00003733866,0.000193234,0.0003650395,0.0001112401,0.0002606731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006544541,0.0001362357,0.001114374,0.0002730593,0.00004749993,0.000001322753,0.0001398943,1.782592e-7,0.9952707,0.00002627307,0.0003136642,0.002611295],"study_design_scores_gemma":[0.0007779564,0.0001119026,0.0008071725,0.0003854818,0.0001616001,0.0001083994,0.0001516511,0.00002140886,0.994779,0.0001787371,0.002238474,0.0002782439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986155,0.0107817,0.001866305,0.00003986821,0.000156128,0.0002130764,0.00003294362,0.00001726141,0.00073766],"genre_scores_gemma":[0.9980388,0.0005172897,0.000746352,0.00003973269,0.0004209918,0.00006827422,0.000113172,0.00002689043,0.00002844656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01188379,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027884147655492,"score_gpt":0.2906119177606641,"score_spread":0.2503330762841092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}