{"id":"W2161620765","doi":"10.1002/cpt.147","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i> and <i>CYP2C19</i> Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":975,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute","keywords":"Fluvoxamine; Escitalopram; Citalopram; CYP2C19; Paroxetine; Pharmacogenetics; Sertraline; Dosing; Medicine; Pharmacology; CYP2D6; Fluoxetine; Psychiatry; Anxiety; Serotonin; Internal medicine; Genotype; Antidepressant; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02583928,0.0008195821,0.001501294,0.002476986,0.001224905,0.002844032,0.004162837,0.009051238,0.01091411],"category_scores_gemma":[0.05979594,0.0008646963,0.003163075,0.002843386,0.001037715,0.001647378,0.002083046,0.009615181,0.007039742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00250002,"about_ca_system_score_gemma":0.01954293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02065548,"about_ca_topic_score_gemma":0.02418243,"domain_scores_codex":[0.9704014,0.01237465,0.00622909,0.001037468,0.008671718,0.001285736],"domain_scores_gemma":[0.9315751,0.02163641,0.006707125,0.002716776,0.03355697,0.003807661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002811859,0.0005303164,0.003967255,0.001248669,0.0001209934,0.0006489553,0.0003597022,0.0008589234,0.001413006,0.00978035,0.7870708,0.1937199],"study_design_scores_gemma":[0.0006351756,0.0003827201,0.01442661,0.005072518,0.0003231428,0.001238687,0.0002422644,0.00135349,0.002020613,0.006825441,0.9673831,0.00009610628],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.011194,0.03651781,0.1409503,0.4023223,0.01582227,0.01378552,0.02858871,0.006784952,0.3440342],"genre_scores_gemma":[0.0707724,0.0400001,0.3788092,0.341719,0.008223399,0.02207383,0.04562235,0.002104449,0.09067523],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02583928,"threshold_uncertainty_score":0.1366528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.294731120690238,"score_gpt":0.567269353284168,"score_spread":0.2725382325939301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}