{"id":"W2161664263","doi":"10.1200/jco.2006.08.1935","title":"Surrogate End Points for Median Overall Survival in Metastatic Colorectal Cancer: Literature-Based Analysis From 39 Randomized Controlled Trials of First-Line Chemotherapy","year":2007,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Surrogate endpoint; Internal medicine; Hazard ratio; Colorectal cancer; Oncology; Randomized controlled trial; Progression-free survival; Proportional hazards model; Clinical endpoint; Population; Chemotherapy; Cancer; Confidence interval; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad"],"consensus_categories":["metaresearch","metaepi_broad"],"category_scores_codex":[0.04339261,0.0007128843,0.06840818,0.001315036,0.00004163154,0.00002136805,0.0002786199,0.0009242506,0.0005458934],"category_scores_gemma":[0.03810213,0.0003657292,0.01960921,0.0008503791,0.0003969653,0.00005693282,0.00003285708,0.001232641,8.19644e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006852209,"about_ca_system_score_gemma":0.004302415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004312498,"about_ca_topic_score_gemma":0.004882596,"domain_scores_codex":[0.9760242,0.006023676,0.01624569,0.0004982756,0.0007736031,0.0004345512],"domain_scores_gemma":[0.8487431,0.1337014,0.01588521,0.0002278042,0.001091866,0.0003506327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5069779,0.001901927,0.0007924853,0.001241256,0.07391882,0.0003253979,0.0001083383,0.00001283071,2.978029e-7,0.000008617473,0.000107749,0.4146044],"study_design_scores_gemma":[0.6976409,0.00705968,0.0006638183,0.006396654,0.1235785,0.0000118152,0.00001802719,0.0002548964,0.000003513391,0.0002910766,0.1638148,0.0002662864],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006499632,0.981919,0.0002974667,0.002561974,0.002375025,0.005367786,0.0008252991,0.000007251541,0.0001465594],"genre_scores_gemma":[0.004460642,0.9898608,0.00287081,0.0004273927,0.001561746,0.0004308372,0.0002584256,0.00005096326,0.00007837392],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4143381,"threshold_uncertainty_score":0.9998795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2130243668631893,"score_gpt":0.5334961922847858,"score_spread":0.3204718254215966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}