{"id":"W2161671616","doi":"10.1038/nsmb.2085","title":"Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":340,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"RNA polymerase II; Enhancer; Promoter; Biology; Transcription factor II D; Transcription (linguistics); Enhancer RNAs; Genetics; Polyadenylation; Chromatin; Cell biology; Transcription factor; Gene; RNA; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990375,0.0003936816,0.0004494633,0.0005586569,0.0008894433,0.001515679,0.0006815825,0.0009936156,0.006102966],"category_scores_gemma":[0.0008989641,0.00101266,0.0005153344,0.0003131668,0.0006468145,0.00127445,0.001461802,0.001459416,0.003010235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008440241,"about_ca_system_score_gemma":0.0004975857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282166,"about_ca_topic_score_gemma":0.002547225,"domain_scores_codex":[0.9994702,0.000032197,0.00002025441,0.0001881,0.00011321,0.0001761104],"domain_scores_gemma":[0.9994538,0.0001424205,0.00007294864,0.00007751714,0.00006274811,0.0001904699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002872077,0.00002193651,0.0009286114,0.00003879686,0.000004782389,0.00007433558,0.00007874641,0.0002049551,0.9928048,0.002141997,0.0002881415,0.003125723],"study_design_scores_gemma":[0.00007643914,0.0001030645,0.0267895,0.00003126378,0.00001461136,0.0003741619,0.0002529768,0.002712763,0.9619251,0.002521497,0.005163311,0.00003533692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596532,0.00372479,0.02441024,0.0005733797,0.0001440541,0.00005679464,0.001204935,0.0007414609,0.009491198],"genre_scores_gemma":[0.9848106,0.0005003875,0.006011609,0.0001450769,0.00005503751,0.00006147558,0.001534417,0.0002407163,0.006640659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006102966,"threshold_uncertainty_score":0.0204165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589547291083249,"score_gpt":0.2716289057660985,"score_spread":0.2557334328552661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}