{"id":"W2161697947","doi":"10.1200/jco.2009.25.0712","title":"Screening for Founder Mutations in <i>BRCA1</i> and <i>BRCA2</i> in Unselected Jewish Women","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Medicine; BRCA mutation; Genetic testing; Family history; Population; Genetic counseling; Christian ministry; Cancer; Gynecology; Demography; Family medicine; Breast cancer; Internal medicine; Genetics; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006202633,0.0002318482,0.0002101871,0.0006027645,0.0006443209,0.0002740246,0.0003204174,0.000481109,0.0009964909],"category_scores_gemma":[0.001372567,0.0002449191,0.0001803997,0.0004582817,0.0004119431,0.0002205168,0.0002236056,0.0001974497,0.0002223218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003863584,"about_ca_system_score_gemma":0.0004215168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03176755,"about_ca_topic_score_gemma":0.06534202,"domain_scores_codex":[0.9996948,0.00009702465,0.00002310541,0.00004663764,0.00007530397,0.00006308922],"domain_scores_gemma":[0.9995787,0.0000816732,0.0001427518,0.00001875432,0.00006902859,0.0001091524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000109038,0.00004091273,0.9973993,0.000008793252,0.00000760653,0.0001948857,0.000167426,0.000007012237,0.0006013429,0.000004625921,0.00009886572,0.001360128],"study_design_scores_gemma":[0.00001277268,0.0002818598,0.9985858,0.000007701822,0.00001538429,0.0006032718,0.0002130369,0.00004776849,0.00009306243,0.00000826649,0.0001288184,0.000002240689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994307,0.0001239524,0.00002079099,0.00003060791,0.000001982102,0.00001638003,0.00005811281,0.000002039025,0.0003153808],"genre_scores_gemma":[0.9993826,0.0001294868,0.0001002456,0.0000803551,0.00000626792,0.00001263184,0.00009590329,8.561297e-7,0.00019155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03176755,"threshold_uncertainty_score":0.06316531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0683974024698686,"score_gpt":0.4275207896189073,"score_spread":0.3591233871490387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}