{"id":"W2161744264","doi":"10.3747/co.v16i4.486","title":"rna Interference and micro-rna–Oriented Therapy in Cancer: Rationales, Promises, and Challenges","year":2009,"lang":"en","type":"article","venue":"Current Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"RNA interference; Small interfering RNA; microRNA; Gene silencing; Trans-acting siRNA; RNA; Computational biology; RNA silencing; DNA-directed RNA interference; Biology; Gene; Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009669572,0.0001316183,0.0001639684,0.00005464419,0.00003229197,0.00001104631,0.00009565149,0.0001166746,0.00001206797],"category_scores_gemma":[0.00002196252,0.0001183134,0.00002255067,0.00003717996,0.00008900915,0.0000063937,0.00004947276,0.0001117852,0.000001573716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002494361,"about_ca_system_score_gemma":0.00009616989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001363208,"about_ca_topic_score_gemma":0.0002054447,"domain_scores_codex":[0.9992083,0.00006605235,0.0001705079,0.0003367062,0.00004349532,0.0001749147],"domain_scores_gemma":[0.9996827,0.00001271705,0.00006231642,0.0001195563,0.0000649711,0.0000577073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002636473,0.0002237101,0.004535579,0.00001925652,0.00001831522,0.000003244628,0.0003061926,0.00000129095,0.3123933,0.0002117203,0.0008769826,0.6811468],"study_design_scores_gemma":[0.005722269,0.007915306,0.1621943,0.0002579877,0.00002794057,0.00006998344,0.0005548514,0.0001548913,0.2343033,0.001150027,0.5868656,0.0007834942],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8862895,0.1111804,0.00004186765,0.001738446,0.0002248228,0.0001725094,0.00001005316,0.000005622949,0.0003367501],"genre_scores_gemma":[0.8028715,0.1966344,0.0000636036,0.0001787932,0.0001285637,0.00003343659,0.00003248068,0.000004579947,0.00005264822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6803633,"threshold_uncertainty_score":0.4824681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09059896348946878,"score_gpt":0.3636150932116169,"score_spread":0.2730161297221481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}