{"id":"W2161744264","doi":"10.3747/co.v16i4.486","title":"rna Interference and micro-rna–Oriented Therapy in Cancer: Rationales, Promises, and Challenges","year":2009,"lang":"en","type":"article","venue":"Current Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"RNA interference; Small interfering RNA; microRNA; Gene silencing; Trans-acting siRNA; RNA; Computational biology; RNA silencing; DNA-directed RNA interference; Biology; Gene; Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008079425,0.0007015423,0.001125682,0.0008134992,0.000659652,0.002461809,0.001343482,0.002476549,0.001509154],"category_scores_gemma":[0.001595825,0.000391114,0.000331176,0.0008176893,0.00750045,0.004709071,0.001463612,0.004168869,0.0005950975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001699696,"about_ca_system_score_gemma":0.002409175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005192385,"about_ca_topic_score_gemma":0.000809546,"domain_scores_codex":[0.9988505,0.000528229,0.00006006167,0.0001130439,0.0003189895,0.0001292608],"domain_scores_gemma":[0.9985552,0.001013344,0.0001101871,0.00007167425,0.0001465091,0.0001030113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005037736,0.0004725926,0.001513481,0.003321581,0.00006439956,0.0008700933,0.0007693163,0.003858581,0.01625785,0.6006697,0.01433338,0.3573652],"study_design_scores_gemma":[0.0002973569,0.001855048,0.001635987,0.001560613,0.00009304589,0.003012389,0.001114821,0.005477583,0.01965906,0.4250859,0.54004,0.0001682199],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007771288,0.9078841,0.02315022,0.04838543,0.0008944382,0.00008306783,0.00004394348,0.000094241,0.0116933],"genre_scores_gemma":[0.1189012,0.8458694,0.01579361,0.01032579,0.003698063,0.0003965824,0.00006631716,0.00004883103,0.004900186],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008079425,"threshold_uncertainty_score":0.0427286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09059896348946878,"score_gpt":0.3636150932116169,"score_spread":0.2730161297221481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}