{"id":"W2161793112","doi":"10.4049/jimmunol.1202937","title":"Enhanced Immunogenicity of a Tricomponent Mannan Tetanus Toxoid Conjugate Vaccine Targeted to Dendritic Cells via Dectin-1 by Incorporating β-Glucan","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Mannan; Toxoid; Immunogenicity; Laminarin; Microbiology; Biology; Immune system; Dendritic cell; Conjugate vaccine; Immunology; Immunization; Polysaccharide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000903904,0.0002896592,0.0002058615,0.0001304256,0.00005061454,0.0001569104,0.0001217586,0.0002296838,0.0003611004],"category_scores_gemma":[0.00007738107,0.00009307685,0.000179943,0.00008223341,0.000105344,0.0001138205,0.0001305077,0.0003744656,0.0001015396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157056,"about_ca_system_score_gemma":0.0001689621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002593609,"about_ca_topic_score_gemma":0.0002801738,"domain_scores_codex":[0.99991,0.00001060076,0.000007675363,0.00001469167,0.00002595215,0.00003110488],"domain_scores_gemma":[0.9999616,0.000005028311,0.0000108099,0.000003782361,0.000006862106,0.00001178993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173508,0.0000669708,0.00008807822,0.00002760196,0.000004171734,0.0000306223,0.000007168132,0.0001136368,0.9983876,0.00002818854,0.00001499939,0.001113666],"study_design_scores_gemma":[0.00005153427,0.001852114,0.00163549,0.000005886906,0.0000274545,0.0002016411,0.00001189202,0.001611767,0.9936829,0.0000332936,0.0008819099,0.00000412737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984025,0.0003334463,0.0008214271,0.00002812918,0.00001997309,0.00002510566,0.00003682991,0.00001590971,0.000316606],"genre_scores_gemma":[0.997793,0.0003076239,0.00111091,0.00003908069,0.000005763038,0.00001956297,0.00009537408,0.000004241685,0.0006245931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003611004,"threshold_uncertainty_score":0.001208067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008311808716103328,"score_gpt":0.2414024450071537,"score_spread":0.2330906362910503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}