{"id":"W2161856772","doi":"10.1016/j.ejphar.2013.01.022","title":"Stereo-selective inhibition of spinal morphine tolerance and hyperalgesia by an ultra-low dose of the alpha-2-adrenoceptor antagonist efaroxan","year":2013,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Les Laboratories Pierre Fabre","keywords":"Morphine; Hyperalgesia; Pharmacology; Opioid; Clonidine; Chemistry; Antagonist; μ-opioid receptor; Nociception; Receptor; Anesthesia; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457817,0.0004155078,0.000474805,0.0002879144,0.0002293796,0.0002235393,0.0004569244,0.0003146218,0.003288778],"category_scores_gemma":[0.0002357309,0.000283704,0.000324702,0.0001533331,0.0003212806,0.0003888058,0.0001920686,0.0009095845,0.0004948975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002963117,"about_ca_system_score_gemma":0.0004202156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191776,"about_ca_topic_score_gemma":0.003330509,"domain_scores_codex":[0.9998621,0.00002001473,0.000008038511,0.00001032345,0.00002393794,0.00007561516],"domain_scores_gemma":[0.9998703,0.00002536498,0.00003178294,0.00001708558,0.00001001875,0.00004538127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004661886,0.0004943676,0.0002740243,0.00008481601,0.00003536949,0.000102402,0.00005770599,0.0001368715,0.9853696,0.0003949887,0.0002399379,0.008148082],"study_design_scores_gemma":[0.00149626,0.01332923,0.02935753,0.00004096781,0.0001139515,0.001281945,0.0001392387,0.002785679,0.9481863,0.0002724758,0.002961216,0.00003529919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956568,0.001190024,0.0008305685,0.0001130963,0.00004106363,0.00004042326,0.000154058,0.00005991253,0.001914021],"genre_scores_gemma":[0.9950494,0.001065563,0.000786347,0.00009017014,0.0000428399,0.00003788541,0.000258596,0.00001957269,0.00264963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003288778,"threshold_uncertainty_score":0.01100206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163905147301249,"score_gpt":0.2690863443852006,"score_spread":0.2574472929121882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}