{"id":"W2161895190","doi":"10.1161/01.res.0000253904.53601.c9","title":"Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca <sup>2+</sup> Cycling","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Heart, Lung, and Blood Institute; University of California, Los Angeles; National Institutes of Health; Compagnia di San Paolo; Società Italiana di Cardiologia; American Heart Association","keywords":"Ryanodine receptor; Endoplasmic reticulum; Chemistry; Calcium; Nitric oxide; Activator (genetics); Contraction (grammar); Myocyte; Calcium in biology; Internal medicine; Biophysics; Intracellular; Endocrinology; Biochemistry; Biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580956,0.0002859871,0.0002671706,0.0001188827,0.00009886778,0.0001961761,0.0002546753,0.0002554705,0.002167305],"category_scores_gemma":[0.00009852831,0.00006264481,0.0001586548,0.00005046787,0.0001731818,0.0002259151,0.0001592798,0.0004096667,0.0002950246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138513,"about_ca_system_score_gemma":0.000154751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000214113,"about_ca_topic_score_gemma":0.0006322023,"domain_scores_codex":[0.9999563,0.00001088649,0.000003424083,0.000008628034,0.000009499849,0.00001129821],"domain_scores_gemma":[0.9999228,0.000012079,0.00002910679,0.000005766423,0.000009939276,0.00002044971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001126085,0.0001572611,0.0003249814,0.0002744547,0.00002174996,0.00007311178,0.00001890637,0.00007109949,0.9800987,0.0003311074,0.0003944903,0.01710808],"study_design_scores_gemma":[0.0003810523,0.00668208,0.01925986,0.00006280355,0.0001675436,0.0005990405,0.00008944172,0.00135412,0.9470872,0.0005408001,0.02375899,0.00001706716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94453,0.04144923,0.005820314,0.001218434,0.0004279096,0.00008218623,0.0003786963,0.0004336818,0.005659615],"genre_scores_gemma":[0.974647,0.01396875,0.004960491,0.0004930942,0.0002168064,0.00004377374,0.0004139509,0.00005230978,0.005203816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002167305,"threshold_uncertainty_score":0.007250369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272713138074764,"score_gpt":0.2822877193528043,"score_spread":0.2695605879720567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}