{"id":"W2161908501","doi":"10.1128/aac.03050-14","title":"Phase 1b Study of New Posaconazole Tablet for Prevention of Invasive Fungal Infections in High-Risk Patients with Neutropenia","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Posaconazole; Neutropenia; Medicine; Mucositis; Pharmacokinetics; Dosing; Internal medicine; Nausea; Pharmacology; Gastroenterology; Chemotherapy; Antifungal; Voriconazole; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001223164,0.001147384,0.001389524,0.0003351977,0.0003127365,0.0006416218,0.0005618904,0.00111244,0.003071962],"category_scores_gemma":[0.0008581643,0.000520174,0.0009625027,0.0002813108,0.0005818185,0.000574382,0.000287862,0.002600854,0.0005648833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005757968,"about_ca_system_score_gemma":0.001639576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007637562,"about_ca_topic_score_gemma":0.00141352,"domain_scores_codex":[0.999639,0.0001843824,0.00001547745,0.00006356521,0.00003660352,0.00006091108],"domain_scores_gemma":[0.999556,0.00008509259,0.00008069784,0.00003727684,0.00004550336,0.0001954547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6726342,0.1344472,0.007948005,0.0008480738,0.0008540385,0.0004279012,0.0003400988,0.003325277,0.07197394,0.000545315,0.00524223,0.1014137],"study_design_scores_gemma":[0.4831802,0.4994378,0.009428022,0.00003212482,0.0001462817,0.0002562613,0.0000309979,0.001246062,0.003928953,0.0001651155,0.002125781,0.00002233189],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896703,0.001850242,0.0008743667,0.0004190188,0.0001010887,0.004533085,0.001113707,0.00007681494,0.001361307],"genre_scores_gemma":[0.9856533,0.001782808,0.002788883,0.001101655,0.0001178498,0.00419073,0.002267766,0.00002891515,0.002067971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003071962,"threshold_uncertainty_score":0.01027673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148178279930801,"score_gpt":0.276525693902587,"score_spread":0.265043911103279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}