{"id":"W2161927295","doi":"10.1038/jid.2010.155","title":"Aldosterone and Mineralocorticoid Receptor Antagonists Modulate Elastin and Collagen Deposition in Human Skin","year":2010,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Dermatological and Skeletal Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Elastin; Aldosterone; Mineralocorticoid receptor; Spironolactone; Eplerenone; Mineralocorticoid; Endocrinology; Extracellular matrix; Internal medicine; Receptor; Chemistry; Fibroblast; Human skin; Lysyl oxidase; Medicine; Biology; Pathology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000987909,0.000140218,0.0002759829,0.0000892193,0.00006479355,0.00002302733,0.00008965728,0.0001906399,0.000008242257],"category_scores_gemma":[0.0001419336,0.0001160658,0.0000394932,0.00007216362,0.0005942046,0.00001484355,0.0000687682,0.0001865154,0.000001261388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004454352,"about_ca_system_score_gemma":0.00003221578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001170328,"about_ca_topic_score_gemma":0.0001492084,"domain_scores_codex":[0.9990352,0.0001305265,0.0004127668,0.0001750272,0.00007498985,0.0001714888],"domain_scores_gemma":[0.9994245,0.00002158523,0.0002426803,0.00008095682,0.00008612662,0.0001441667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004563679,0.00004606353,0.01320324,0.00002361905,0.00002629876,0.00006362268,0.000102875,0.000003707446,0.9851744,0.0002591792,0.000687109,0.000364227],"study_design_scores_gemma":[0.001356702,0.0003223961,0.07172565,0.00002515274,0.0000165223,0.003021887,0.00009187675,0.00008980519,0.9195462,0.00241969,0.001199796,0.0001842883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971139,0.0003502744,0.00007050044,0.002147049,0.00008491239,0.000100823,0.000004444278,0.000002767893,0.0001252914],"genre_scores_gemma":[0.9971849,0.00008284244,0.002102034,0.0005317153,0.00003990357,0.000004669636,0.00001744178,0.000009405405,0.00002703544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06562819,"threshold_uncertainty_score":0.4733026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006627867856429256,"score_gpt":0.2352369838822577,"score_spread":0.2286091160258285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}