{"id":"W2161963674","doi":"10.1371/journal.pone.0069552","title":"Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alcon Research Institute; National Eye Institute; Canadian Institutes of Health Research; BrightFocus Foundation; Charles H. Hood Foundation; National Institutes of Health; V. Kann Rasmussen Foundation; Research to Prevent Blindness","keywords":"Angiogenesis; Ex vivo; Sprouting angiogenesis; Matrigel; Choroid; Neovascularization; Biology; Pathology; In vivo; Choroidal neovascularization; Cell biology; Retina; Cancer research; Medicine; Retinal; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007746599,0.001413625,0.0004894387,0.0008815267,0.0004804433,0.0003468713,0.0004054062,0.0005377834,0.001581662],"category_scores_gemma":[0.0002221131,0.0003339139,0.0004957597,0.0005289181,0.0003744438,0.0004350268,0.0003356113,0.001505961,0.0004924546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004578485,"about_ca_system_score_gemma":0.0004260302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794476,"about_ca_topic_score_gemma":0.003016133,"domain_scores_codex":[0.9993212,0.0001492908,0.00007023877,0.0001744886,0.0002013654,0.00008345444],"domain_scores_gemma":[0.9994833,0.0001539342,0.0001045134,0.00009140887,0.00008492054,0.00008186504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004316798,0.00003813116,0.0001096844,0.00003944869,0.000005284178,0.00005010315,0.00002017135,0.0000713439,0.9990028,0.00007484738,0.00005461625,0.0004905373],"study_design_scores_gemma":[0.00001173683,0.0003496109,0.001959188,0.00000569747,0.00002849692,0.0002287702,0.00001398043,0.001198834,0.9945057,0.00004064015,0.001647922,0.000009454971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7478269,0.006257695,0.2322037,0.0002351357,0.0003007595,0.0007826756,0.002999453,0.001598871,0.007794768],"genre_scores_gemma":[0.835967,0.004870389,0.1438707,0.0001469884,0.00008096745,0.001390953,0.003118729,0.0002846369,0.01026976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794476,"threshold_uncertainty_score":0.005291224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05321981070190954,"score_gpt":0.2426260897760927,"score_spread":0.1894062790741831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}