{"id":"W2161963674","doi":"10.1371/journal.pone.0069552","title":"Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alcon Research Institute; National Eye Institute; Canadian Institutes of Health Research; BrightFocus Foundation; Charles H. Hood Foundation; National Institutes of Health; V. Kann Rasmussen Foundation; Research to Prevent Blindness","keywords":"Angiogenesis; Ex vivo; Sprouting angiogenesis; Matrigel; Choroid; Neovascularization; Biology; Pathology; In vivo; Choroidal neovascularization; Cell biology; Retina; Cancer research; Medicine; Retinal; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006133684,0.0001103891,0.0002780756,0.00004968779,0.00002974895,0.00001015253,0.00005828166,0.000046779,0.0002592088],"category_scores_gemma":[0.00003577399,0.00009118127,0.0001437781,0.00007500425,0.0000258639,0.00008566003,0.0000257396,0.00003671965,0.00009312251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002880823,"about_ca_system_score_gemma":0.00003195804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002702379,"about_ca_topic_score_gemma":0.000001874916,"domain_scores_codex":[0.9991459,0.00002351072,0.0001724895,0.0001944564,0.0002826074,0.0001810943],"domain_scores_gemma":[0.9992859,0.00001185971,0.00005920363,0.0003361831,0.0001371355,0.0001697706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006558249,0.004671855,0.1238136,0.0003040747,0.001140455,0.00001367293,0.0001070585,0.00002257612,0.8673866,0.00003132332,0.00006005077,0.002383123],"study_design_scores_gemma":[0.002848267,0.0007744749,0.1524961,0.0006925989,0.003394827,0.000008001072,0.0001474077,0.0689556,0.7698168,0.0005341524,0.00001029195,0.0003215118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972922,0.0006586763,0.0000922465,0.0001303087,0.000005277743,0.0004460066,0.00001413484,0.00003592554,0.001325204],"genre_scores_gemma":[0.9900668,0.0000803978,0.008870399,0.0001069779,0.00005243915,0.00003168848,0.00003002935,0.00002620906,0.0007350329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09756988,"threshold_uncertainty_score":0.3718264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05321981070190954,"score_gpt":0.2426260897760927,"score_spread":0.1894062790741831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}