{"id":"W2161984795","doi":"10.18632/aging.100679","title":"WI-38 senescence is associated with global and site-specific hypomethylation","year":2014,"lang":"en","type":"article","venue":"Aging","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Cancer Foundation","keywords":"Senescence; DNA methylation; Biology; CpG site; Methylation; Gene expression; Gene; Regulation of gene expression; Epigenetics; DNA; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557645,0.0003165501,0.0002381501,0.000557373,0.0001703238,0.0001903824,0.0001374023,0.0001407898,0.001278867],"category_scores_gemma":[0.0002159323,0.0001439334,0.0002148851,0.0002605804,0.00021651,0.0001336273,0.0002532582,0.0002886995,0.0002868194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002353386,"about_ca_system_score_gemma":0.0002352224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001549117,"about_ca_topic_score_gemma":0.002013676,"domain_scores_codex":[0.9998863,0.00001477896,0.00001442218,0.00003507755,0.00002745292,0.00002201071],"domain_scores_gemma":[0.9998173,0.00001509603,0.00007699544,0.00003276959,0.00002564913,0.0000321843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310625,0.00001259539,0.003919901,0.00003245274,0.00001978866,0.00009249979,0.00003593133,0.00003866116,0.9931147,0.00009425692,0.00005544361,0.002452831],"study_design_scores_gemma":[0.00001514903,0.0006096634,0.2025577,0.00002058239,0.00009313,0.002667887,0.0001154439,0.001058646,0.7830116,0.0006129494,0.009218012,0.00001923124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872153,0.005703051,0.004522646,0.00008577041,0.00002814464,0.00002678056,0.0006367794,0.00008693484,0.001694645],"genre_scores_gemma":[0.9950069,0.001097438,0.001147036,0.00003303685,0.000007132736,0.00002635007,0.0005503938,0.00001216155,0.002119501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549117,"threshold_uncertainty_score":0.004278243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383129596737013,"score_gpt":0.2401650548188379,"score_spread":0.2263337588514678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}