{"id":"W2161984795","doi":"10.18632/aging.100679","title":"WI-38 senescence is associated with global and site-specific hypomethylation","year":2014,"lang":"en","type":"article","venue":"Aging","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Cancer Foundation","keywords":"Senescence; DNA methylation; Biology; CpG site; Methylation; Gene expression; Gene; Regulation of gene expression; Epigenetics; DNA; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288297,0.0001434934,0.0002302222,0.00005413789,0.0001143751,0.00004019563,0.00004898789,0.00006380177,0.00004462367],"category_scores_gemma":[0.0001097665,0.000119524,0.0000275349,0.0003430659,0.00008472672,0.00009880109,0.00002506784,0.000118559,0.00003131361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007619552,"about_ca_system_score_gemma":0.00002801153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007387482,"about_ca_topic_score_gemma":0.00003949716,"domain_scores_codex":[0.9989516,0.00004618395,0.0001554063,0.000309043,0.0002745599,0.0002632004],"domain_scores_gemma":[0.9993734,0.00009803865,0.00007902262,0.0002159854,0.00009709492,0.0001364625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008390794,0.00007136659,0.8986868,0.00005119009,0.00004092504,0.00005610992,0.001273878,0.000004679806,0.01893906,0.0002833882,0.001316293,0.07919238],"study_design_scores_gemma":[0.001706513,0.0001960009,0.9802796,0.0003883213,0.00006316184,0.00009282623,0.0001887985,0.002245901,0.003956808,0.0001959125,0.01038674,0.0002994241],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936259,0.0005127552,0.002233759,0.0009955912,0.00008145065,0.0001293996,0.000007819644,0.0001190855,0.00229428],"genre_scores_gemma":[0.9973957,0.00009421356,0.001245535,0.0007605544,0.0001181305,0.000002515859,0.00002469069,0.00001464131,0.0003440271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08159277,"threshold_uncertainty_score":0.4874048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383129596737013,"score_gpt":0.2401650548188379,"score_spread":0.2263337588514678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}