{"id":"W2162003888","doi":"10.1158/0008-5472.can-08-4450","title":"<i>PIK3CA</i> and <i>PIK3CB</i> Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor–Positive Breast Cancer","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Pfizer","keywords":"Cancer research; P110α; Estrogen receptor; Breast cancer; Estrogen; Cancer; RNA interference; Synthetic lethality; PI3K/AKT/mTOR pathway; Biology; Estrogen receptor alpha; Mutant; Chemistry; Internal medicine; Apoptosis; Medicine; Endocrinology; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008416683,0.0002554064,0.0002528085,0.0001266332,0.0001727028,0.00007887156,0.0002352495,0.0002033178,0.00006553352],"category_scores_gemma":[0.00007594526,0.0002389389,0.00004638753,0.0004038789,0.0003273525,0.00002986177,0.0001160483,0.000429533,0.000005398349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000317825,"about_ca_system_score_gemma":0.0005613485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123462,"about_ca_topic_score_gemma":0.0004393918,"domain_scores_codex":[0.9973279,0.0003225576,0.0002813446,0.0008922524,0.0005400744,0.0006358944],"domain_scores_gemma":[0.9987099,0.0000389339,0.0001011308,0.0004852584,0.0004893029,0.0001754545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001898909,0.0001509498,0.02728511,0.00005200759,0.00006608025,0.00001070388,0.0002449157,0.0001840348,0.9551813,0.0001676837,0.001843545,0.01291476],"study_design_scores_gemma":[0.001640436,0.0008688385,0.01512235,0.0003411684,0.00002778422,0.00003457553,0.00008099651,0.00002924331,0.978774,0.0004532267,0.002237596,0.0003898318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910431,0.00343902,0.0001022961,0.004037442,0.00007465811,0.000836394,0.0002018295,0.00002442233,0.000240872],"genre_scores_gemma":[0.9974115,0.0008396042,0.0002798453,0.0004293712,0.0003110491,0.0004354249,0.0001304702,0.00004292417,0.0001198036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02359266,"threshold_uncertainty_score":0.9743645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220956555352251,"score_gpt":0.3214321773304566,"score_spread":0.2992226117769342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}