{"id":"W2162013503","doi":"10.1016/j.exphem.2006.11.012","title":"Polycythemia vera is not initiated by JAK2 mutation","year":2006,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":199,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Polycythemia vera; Allele; Mutation; Somatic cell; Biology; Mutant; Erythropoietin; Haematopoiesis; Genetics; Mutation frequency; Germline mutation; Immunology; Stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002915065,0.0002037558,0.0003626842,0.00006582816,0.00009304182,0.00001332553,0.00004248815,0.0001260236,0.001479689],"category_scores_gemma":[0.000007583724,0.0001767801,0.00008243759,0.00009217696,0.00008599724,0.0000616982,0.00002598278,0.00009286914,0.0003957978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001312765,"about_ca_system_score_gemma":0.00003802857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002158294,"about_ca_topic_score_gemma":0.000006304894,"domain_scores_codex":[0.9989078,0.00003596464,0.0002916177,0.000321619,0.00017806,0.0002649449],"domain_scores_gemma":[0.9995648,0.0000592782,0.0000778637,0.0001725529,0.00003565256,0.00008988408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002256912,0.01017366,0.1534096,0.0001363809,0.0006627403,0.002651877,0.003549446,0.000002182602,0.3035296,0.1360647,0.3862597,0.001303172],"study_design_scores_gemma":[0.003132341,0.0004909702,0.003064058,0.00002926903,0.00003145962,0.000831213,0.000219762,0.00005610521,0.9882038,0.00009280629,0.00370373,0.0001444465],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825279,0.004252005,0.00003547638,0.002162267,0.0001532192,0.0004105578,0.00003634796,0.00009022703,0.01033196],"genre_scores_gemma":[0.9957777,0.00001240989,0.000528304,0.00225326,0.00006766646,0.0001915694,0.0003548814,0.00002658783,0.0007876556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6846743,"threshold_uncertainty_score":0.9994331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997845871133661,"score_gpt":0.3134519333722287,"score_spread":0.2934734746608921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}