{"id":"W2162069507","doi":"10.1186/s12920-015-0140-y","title":"The impact of direct-to-consumer personal genomic testing on perceived risk of breast, prostate, colorectal, and lung cancer: findings from the PGen study","year":2015,"lang":"en","type":"article","venue":"BMC Medical Genomics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Human Genome Research Institute; Canadian Institutes of Health Research; National Center for Research Resources; School of Public Health, University of Michigan; Brigham and Women's Hospital; University of Minnesota; National Cancer Institute; National Institutes of Health","keywords":"Medicine; Breast cancer; Internal medicine; Oncology; Colorectal cancer; Prostate cancer; Family history; Cancer; Prostate; Lung cancer; Genotyping; Gynecology; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003414096,0.0002013669,0.0001955464,0.000254319,0.0003079309,0.0008098929,0.0004149903,0.0004667631,0.001939686],"category_scores_gemma":[0.009138979,0.0001872458,0.0004783793,0.0003972968,0.0004529251,0.0005538012,0.001138859,0.0009284543,0.0001575085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004422893,"about_ca_system_score_gemma":0.000484935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007690573,"about_ca_topic_score_gemma":0.009858184,"domain_scores_codex":[0.9981212,0.001138082,0.00008222057,0.000226341,0.0003262087,0.0001059122],"domain_scores_gemma":[0.9933327,0.003273009,0.001816131,0.0005249675,0.0003857834,0.0006674184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004731817,0.0002054159,0.9927773,0.00003781628,0.0001225648,0.00007970496,0.001739032,0.00002852904,0.0001134205,0.00004852698,0.0001573445,0.004217111],"study_design_scores_gemma":[0.0000253272,0.0002168677,0.9975843,0.00001538345,0.00006423514,0.00007659072,0.001379274,0.0001009796,0.0000490332,0.00004281812,0.0004396023,0.000005577986],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991916,0.00008522274,0.00003244499,0.0001254204,0.000003064245,0.000007784765,0.0001049689,8.209511e-7,0.0004485601],"genre_scores_gemma":[0.9993625,0.00007692094,0.000081149,0.00008586251,0.000006142274,0.00001248331,0.00009802273,0.000001905181,0.0002749184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007690573,"threshold_uncertainty_score":0.01805568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194184477759631,"score_gpt":0.3038516862092219,"score_spread":0.2844332384332587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}