{"id":"W2162074485","doi":"10.1158/0008-5472.can-13-1175","title":"Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; University of Leicester","keywords":"EIF4E; Translation (biology); Initiation factor; Casein kinase 1; Translational regulation; EIF4A1; Eukaryotic translation; Biology; Messenger RNA; Cell biology; Eukaryotic initiation factor; Cancer research; Eukaryotic translation initiation factor 4 gamma; Phosphorylation; Protein kinase A; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937108,0.0004199498,0.000193741,0.0003213609,0.0001921025,0.0003273686,0.000136993,0.0001753039,0.001223984],"category_scores_gemma":[0.0001199866,0.0001163572,0.0001650549,0.0001771298,0.0002159779,0.0001745225,0.000214998,0.0004045471,0.0004217687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004530142,"about_ca_system_score_gemma":0.0002723945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052439,"about_ca_topic_score_gemma":0.0004482124,"domain_scores_codex":[0.9998895,0.00001515831,0.000007815756,0.0000279608,0.00003486804,0.00002453395],"domain_scores_gemma":[0.9999313,0.000009417949,0.00002829989,0.000004797253,0.00001227473,0.0000138708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001774283,0.00003050848,0.0004365904,0.0001581367,0.000009696033,0.00007246679,0.00001347322,0.0001062932,0.9890559,0.0005078887,0.0002224179,0.009209163],"study_design_scores_gemma":[0.00003364156,0.0002807111,0.01097668,0.00002163247,0.00003126225,0.0004348852,0.00003340759,0.0008943481,0.9656452,0.0004719309,0.02116462,0.0000117085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8919755,0.0815069,0.01151765,0.001080471,0.0005510428,0.00007077023,0.0006089058,0.0003948723,0.0122939],"genre_scores_gemma":[0.9803263,0.01309795,0.002492061,0.00009564304,0.00009532559,0.00003138454,0.0002811824,0.00001963637,0.003560404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223984,"threshold_uncertainty_score":0.004094601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05159236650077313,"score_gpt":0.3621973439093495,"score_spread":0.3106049774085764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}