{"id":"W2162076272","doi":"10.1371/journal.pone.0044411","title":"Are Plasma Biomarkers of Immune Activation Predictive of HIV Progression: A Longitudinal Comparison and Analyses in HIV-1 and HIV-2 Infections?","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council","keywords":"Neopterin; SuPAR; Biomarker; Medicine; Immunology; Immune system; Internal medicine; Multicenter AIDS Cohort Study; Viral load; Human immunodeficiency virus (HIV); Biology; Urokinase; Antiretroviral therapy; Urokinase receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005548951,0.0002965375,0.0004496481,0.000784955,0.0004173854,0.0007299477,0.0004310792,0.0007183087,0.000832553],"category_scores_gemma":[0.008265252,0.0002442743,0.0006351967,0.0008140854,0.0003437076,0.0007876671,0.0005130735,0.0007286432,0.0002199215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406688,"about_ca_system_score_gemma":0.0003348422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001465983,"about_ca_topic_score_gemma":0.001303092,"domain_scores_codex":[0.9983314,0.0008327361,0.0001288076,0.000356911,0.0001913031,0.0001590061],"domain_scores_gemma":[0.994225,0.002247397,0.001689698,0.000705014,0.0006111666,0.0005216943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004782609,0.00003100707,0.9974533,0.000006718213,0.0001136758,0.00002235028,0.000049355,0.00003433241,0.0003156014,0.00001030704,0.00003636084,0.00144879],"study_design_scores_gemma":[0.00001059364,0.0003999695,0.9985189,0.000007320637,0.00008722643,0.0001732426,0.0001007597,0.000309907,0.0001665834,0.0000386946,0.0001825909,0.000004305522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998414,0.0007611586,0.0003162409,0.00004409876,0.00001006699,0.00001172114,0.0002473284,0.000004123178,0.0001910932],"genre_scores_gemma":[0.998889,0.0001452737,0.000215712,0.00003632352,0.0000205824,0.00001898169,0.000550301,0.000002549543,0.0001211805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005548951,"threshold_uncertainty_score":0.02934605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104123153767523,"score_gpt":0.3679547237451725,"score_spread":0.2638315699776495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}