{"id":"W2162082544","doi":"10.1096/fj.09-147819","title":"MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase‐6 regulates astrocyte survival","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; Montreal Clinical Research Institute; University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Neurodegeneration; Biology; Astrocyte; microRNA; Gene expression profiling; Caspase; Programmed cell death; Caspase 3; Cell biology; Microarray analysis techniques; Gene expression; Molecular biology; Caspase 8; Apoptosis; Gene; Pathology; Genetics; Central nervous system; Medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264266,0.0002096715,0.0002026453,0.000366973,0.000167601,0.0004261193,0.00008710572,0.000276818,0.0006456994],"category_scores_gemma":[0.0002347438,0.0001131521,0.0001778079,0.0002386284,0.000173829,0.0002598121,0.0001423087,0.0003322436,0.0002517226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001277496,"about_ca_system_score_gemma":0.0001017363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001607177,"about_ca_topic_score_gemma":0.0002989623,"domain_scores_codex":[0.9998779,0.00001832676,0.00001450993,0.00003799413,0.00003158967,0.00001956065],"domain_scores_gemma":[0.9999324,0.00001398104,0.00001756733,0.000008716321,0.00001788966,0.000009472762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545295,0.00001014867,0.002979351,0.00005145453,0.00001375868,0.0001791007,0.00005098536,0.00004565663,0.9911768,0.0001313584,0.00005005976,0.005156873],"study_design_scores_gemma":[0.00001939417,0.0003544964,0.08941668,0.0000239968,0.00007328644,0.003823745,0.0001700714,0.001603605,0.8994569,0.0007116764,0.004329824,0.00001651068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871157,0.004507299,0.005774525,0.0001940231,0.00002670039,0.00002015524,0.0006534273,0.00007974647,0.001628528],"genre_scores_gemma":[0.9914523,0.00170823,0.005362283,0.00008713279,0.00001529866,0.00001999005,0.0004414856,0.0000138165,0.0008995451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006456994,"threshold_uncertainty_score":0.002160072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181748715700545,"score_gpt":0.2383604266417289,"score_spread":0.2265429394847234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}