{"id":"W2162084860","doi":"10.1073/pnas.1115024109","title":"Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Killam Trusts; Alberta Innovates - Health Solutions","keywords":"Neuroscience; Excitatory postsynaptic potential; Postsynaptic potential; Parallel fiber; Purkinje cell; Hyperpolarization (physics); SK channel; Electrophysiology; Biophysics; Ion channel; Chemistry; Inhibitory postsynaptic potential; Biology; Cerebellum; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007517261,0.0002404569,0.0002604985,0.0001263431,0.0001243375,0.0003592048,0.000237347,0.0002716483,0.0005476585],"category_scores_gemma":[0.0001845819,0.0001206678,0.0001432183,0.0001202082,0.0002597851,0.0003261745,0.0002447069,0.0004642051,0.000212081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000554625,"about_ca_system_score_gemma":0.0001885213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251733,"about_ca_topic_score_gemma":0.001803562,"domain_scores_codex":[0.9999317,0.000005227991,0.000006028121,0.00001775935,0.00001836245,0.00002083423],"domain_scores_gemma":[0.9998907,0.0000133112,0.00002986319,0.000008796096,0.00001429396,0.00004298839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004215223,0.00000876442,0.000208225,0.000009506296,0.000001735717,0.00003158613,0.000007396101,0.00005307366,0.9989863,0.00003732034,0.00001022306,0.0006037169],"study_design_scores_gemma":[0.00005906926,0.0001909316,0.08713756,0.000008545663,0.00004140786,0.0003636732,0.00007495893,0.00644628,0.9040948,0.000403552,0.001164979,0.00001428637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996669,0.0004496,0.002113463,0.00004289964,0.00001228628,0.000006697954,0.00007108809,0.0001038366,0.0005310617],"genre_scores_gemma":[0.9986784,0.000217912,0.0005421156,0.00002239994,0.000004351821,0.000009513422,0.00004794092,0.00001945282,0.0004579092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251733,"threshold_uncertainty_score":0.004024088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04216268252208101,"score_gpt":0.2921490693825669,"score_spread":0.2499863868604859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}