{"id":"W2162086299","doi":"10.1073/pnas.0805493105","title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; McGill University","keywords":"Olanzapine; Reelin; Haloperidol; Clozapine; Pharmacology; Internal medicine; Endocrinology; DNA demethylation; Striatum; Chemistry; Medicine; Dopamine; Biochemistry; Schizophrenia (object-oriented programming); DNA methylation; Psychiatry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007459606,0.00008610953,0.0001082134,0.0000734464,0.0001842719,0.00001014956,0.0002547176,0.00009660154,0.000005681338],"category_scores_gemma":[0.0008991336,0.00005645362,0.00004055814,0.0002133232,0.000495352,0.00002555679,0.0001148785,0.00006934415,3.406608e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007859915,"about_ca_system_score_gemma":0.00004042405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008427717,"about_ca_topic_score_gemma":3.526648e-7,"domain_scores_codex":[0.9989542,0.000009452305,0.0002445042,0.0002283706,0.000454206,0.0001093041],"domain_scores_gemma":[0.9994358,0.00004843909,0.000267323,0.00001006159,0.0002054192,0.00003300273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006394617,0.00001551956,0.004815042,0.00001898954,0.00001000523,5.323933e-9,0.00004954003,0.00004635394,0.9932283,0.0006928151,0.0001932015,0.0008662689],"study_design_scores_gemma":[0.0002317717,0.0001015176,0.09910328,0.00001565253,0.000004401755,0.00000707958,0.00001873041,0.0002346007,0.895975,0.001025881,0.003213173,0.00006891897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965722,0.0004461228,0.00001416353,0.00208876,0.00001465337,0.000124395,0.00001233433,0.000003630353,0.0007237591],"genre_scores_gemma":[0.9965033,0.0007712885,0.001673901,0.0003097936,0.0001191615,0.000005440143,9.933863e-7,0.000004860219,0.000611294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09725332,"threshold_uncertainty_score":0.2302112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05571572341055721,"score_gpt":0.3128267658038399,"score_spread":0.2571110423932827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}