{"id":"W2162086299","doi":"10.1073/pnas.0805493105","title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; McGill University","keywords":"Olanzapine; Reelin; Haloperidol; Clozapine; Pharmacology; Internal medicine; Endocrinology; DNA demethylation; Striatum; Chemistry; Medicine; Dopamine; Biochemistry; Schizophrenia (object-oriented programming); DNA methylation; Psychiatry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006359419,0.0004564499,0.000193529,0.0002811237,0.00007379478,0.0002035316,0.0001183566,0.0002406401,0.0009324814],"category_scores_gemma":[0.00009091313,0.0001575376,0.0002387968,0.0001119924,0.0001800083,0.0001182021,0.0001054453,0.0003502372,0.0001877224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319498,"about_ca_system_score_gemma":0.00023468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001876948,"about_ca_topic_score_gemma":0.005983684,"domain_scores_codex":[0.9998975,0.00001727177,0.000007739744,0.00001524807,0.00002760211,0.00003457287],"domain_scores_gemma":[0.9999115,0.000008255438,0.00003824046,0.000006257694,0.00000761664,0.00002802442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003605007,0.0000180834,0.0002633194,0.00001269744,0.000008193881,0.00004314856,0.00000877584,0.00002201603,0.9985448,0.00002818843,0.00001841683,0.0006717159],"study_design_scores_gemma":[0.00007563974,0.001687639,0.01383643,0.000006585934,0.00004254773,0.0004160849,0.00006829143,0.0005046592,0.9823657,0.00005636641,0.0009341607,0.000005967176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979347,0.0004969597,0.0003868748,0.00005442181,0.0000125597,0.00001364092,0.0002626991,0.00005616686,0.0007818888],"genre_scores_gemma":[0.9972235,0.0006001968,0.0005894648,0.00004729676,0.000005015317,0.00002916963,0.0003047932,0.000009387341,0.001191298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876948,"threshold_uncertainty_score":0.003732026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05571572341055721,"score_gpt":0.3128267658038399,"score_spread":0.2571110423932827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}