{"id":"W2162111025","doi":"10.1128/jvi.01242-13","title":"Adenovirus E4orf4 Protein-Induced Death of p53 <sup>−/−</sup> H1299 Human Cancer Cells Follows a G <sub>1</sub> Arrest of both Tetraploid and Diploid Cells due to a Failure To Initiate DNA Synthesis","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Ploidy; Molecular biology; Programmed cell death; Apoptosis; Cancer cell; P53 protein; Genetics; Cell biology; Cancer research; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009980013,0.0003306362,0.0001905106,0.0002262445,0.0001479142,0.0001861594,0.0001190235,0.0001937892,0.001520925],"category_scores_gemma":[0.00007205975,0.0001075407,0.0002562377,0.0001325622,0.0002163827,0.0001327246,0.0001324449,0.0003657619,0.0003498513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041444,"about_ca_system_score_gemma":0.0001649605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006241582,"about_ca_topic_score_gemma":0.000698937,"domain_scores_codex":[0.9999198,0.00001288602,0.00001098581,0.00001963494,0.00001815128,0.0000185968],"domain_scores_gemma":[0.9999404,0.00001740412,0.00001516449,0.00001125762,0.000005159397,0.00001065868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009460152,0.00001628064,0.0002002132,0.00001583873,0.000004616108,0.00005177125,0.000007505363,0.00003583683,0.9987017,0.00006970876,0.00002045636,0.0007813615],"study_design_scores_gemma":[0.00001001846,0.0002141181,0.003162215,0.000002127835,0.000005860547,0.0002317318,0.000008733831,0.0003681854,0.9952492,0.00003424727,0.0007114731,0.000002181884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952773,0.0007107056,0.00225144,0.00004744053,0.00002233773,0.00003116583,0.0004588809,0.00005998829,0.001140736],"genre_scores_gemma":[0.9948384,0.0004892786,0.001841135,0.00002562662,0.000003944309,0.00002582919,0.0008241712,0.00001134646,0.00194036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520925,"threshold_uncertainty_score":0.005088031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594632686396654,"score_gpt":0.2739604983383378,"score_spread":0.2580141714743713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}