{"id":"W2162124810","doi":"10.1021/jo9917947","title":"Effect of Chain Length and Ring Size of Alkyl and Cycloalkyl Side-Chain Substituents upon the Biological Activity of Brassinosteroids. Preparation of Novel Analogues with Activity Exceeding that of Brassinolide","year":2000,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Brassinolide; Brassinosteroid; Substituent; Ether; Stereochemistry; Alkyl; Grignard reaction; Ethylenedioxy; Epoxide; Organic chemistry; Reagent; Catalysis; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001035668,0.0001409721,0.0004547341,0.000008212724,0.00005723497,0.000008594043,0.0002177853,0.00009982928,0.00006177581],"category_scores_gemma":[0.0001354531,0.00004544116,0.00007158659,0.0001399584,0.0002457268,0.0001114408,0.00005710865,0.0001728298,3.309745e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001263677,"about_ca_system_score_gemma":0.00001635631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001829288,"about_ca_topic_score_gemma":0.00005021839,"domain_scores_codex":[0.9990654,0.000123418,0.0003302613,0.0001118545,0.0002400049,0.0001290828],"domain_scores_gemma":[0.9974887,0.001430397,0.0009038257,0.00007272229,0.0000576274,0.00004670384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001015619,0.00009933714,0.02169525,0.000102735,0.00006699911,7.751159e-7,0.0001980855,0.00001402236,0.9681676,6.282298e-7,0.000001238672,0.008637727],"study_design_scores_gemma":[0.0003652403,0.0005289923,0.1625298,0.0001779592,0.00006989542,0.00008794695,0.0001017008,0.0000635472,0.8360072,0.00000877117,0.000001644538,0.00005738482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993402,0.0003416099,0.00000797104,0.00007984552,0.0000122118,0.000102274,0.00003845729,0.000002705666,0.00007465899],"genre_scores_gemma":[0.9993372,0.0005936831,0.0000137781,0.000003280674,0.0000373562,3.127338e-7,0.00000137492,0.000001357151,0.00001167024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1408345,"threshold_uncertainty_score":0.1853037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561565385551633,"score_gpt":0.2247386976720407,"score_spread":0.2091230438165244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}