{"id":"W2162133181","doi":"10.1155/2015/515307","title":"Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis","year":2015,"lang":"en","type":"review","venue":"Journal of Diabetes Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Islet; Fibrillogenesis; Chemistry; Amyloid (mycology); Fibril; Biochemistry; Protein aggregation; Amyloid fibril; Peptide; Biophysics; Insulin; Endocrinology; Internal medicine; Biology; Amyloid β; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004688364,0.0006919872,0.001102905,0.002084959,0.0003139204,0.0009949883,0.0008198762,0.0008816112,0.002620072],"category_scores_gemma":[0.0005871626,0.0002532969,0.0005101864,0.001955392,0.0004908728,0.001261761,0.0007069444,0.001173242,0.001352764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005650661,"about_ca_system_score_gemma":0.001037835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008080266,"about_ca_topic_score_gemma":0.001246833,"domain_scores_codex":[0.9998715,0.00002352904,0.00002038328,0.00002315326,0.00004499515,0.00001650556],"domain_scores_gemma":[0.9998019,0.0000843282,0.0000325094,0.000005857652,0.00005334951,0.00002192929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001443483,0.0001296679,0.0003334022,0.03731716,0.0001347256,0.0004953928,0.0001572551,0.0005328644,0.004341303,0.008831029,0.01911477,0.928468],"study_design_scores_gemma":[0.00002204458,0.000110184,0.001111979,0.005267881,0.0001602753,0.001591243,0.0001198041,0.00009777283,0.001042155,0.004342506,0.9861114,0.00002282836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001474471,0.9989985,0.0000563832,0.0001137914,0.00006315709,0.000002528438,0.000009074334,0.000002763064,0.0006064242],"genre_scores_gemma":[0.0008121312,0.9987671,0.00008339091,0.00006214167,0.00004533686,0.000003388737,0.00001243625,4.356612e-7,0.0002136785],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002620072,"threshold_uncertainty_score":0.008764982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2077642264158276,"score_gpt":0.4701324016951544,"score_spread":0.2623681752793268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}