{"id":"W2162133181","doi":"10.1155/2015/515307","title":"Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis","year":2015,"lang":"en","type":"review","venue":"Journal of Diabetes Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Islet; Fibrillogenesis; Chemistry; Amyloid (mycology); Fibril; Biochemistry; Protein aggregation; Amyloid fibril; Peptide; Biophysics; Insulin; Endocrinology; Internal medicine; Biology; Amyloid β; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004169419,0.0003902674,0.003260039,0.002006607,0.00008339987,0.00003901157,0.0005367043,0.000400379,0.0002826048],"category_scores_gemma":[0.003463927,0.0002443363,0.0009418587,0.001556143,0.0004534012,0.00009471698,0.0002372947,0.001686631,0.0001113551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098899,"about_ca_system_score_gemma":0.004379823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004011638,"about_ca_topic_score_gemma":0.000003083513,"domain_scores_codex":[0.9933579,0.001605207,0.001515141,0.0003418527,0.002099849,0.001080052],"domain_scores_gemma":[0.9936867,0.001660939,0.0006236195,0.0004668024,0.002420706,0.001141204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001305856,0.01290225,0.05056969,0.03587833,0.06645659,0.005178282,0.0001869502,0.000002206337,0.0008323949,0.000736871,0.01310485,0.8128457],"study_design_scores_gemma":[0.01624847,0.02256307,0.006175878,0.08814105,0.01282269,0.0005771115,0.0005714583,0.00003433443,0.002640054,0.004572208,0.8439112,0.001742435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01783464,0.9800199,0.000002171603,0.00008855596,0.00008809185,0.00112749,0.0006472454,0.000007683395,0.0001842012],"genre_scores_gemma":[0.06338739,0.935929,0.00009456351,0.000007415774,0.0002753749,0.0000643727,0.0001514049,0.0000491211,0.00004132759],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8308064,"threshold_uncertainty_score":0.9963747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2077642264158276,"score_gpt":0.4701324016951544,"score_spread":0.2623681752793268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}