{"id":"W2162160107","doi":"10.1158/1535-7163.mct-10-0471","title":"RITA Inhibits Multiple Myeloma Cell Growth through Induction of p53-Mediated Caspase-Dependent Apoptosis and Synergistically Enhances Nutlin-Induced Cytotoxic Responses","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada","keywords":"Downregulation and upregulation; Apoptosis; Mdm2; Cancer research; Cytotoxic T cell; Multiple myeloma; Caspase; Biology; Cell culture; Caspase 8; Programmed cell death; Gene; Immunology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547708,0.0004865004,0.0005524992,0.00044498,0.0001091415,0.0002160054,0.0002710233,0.0001764215,0.0009001936],"category_scores_gemma":[0.0001188451,0.0001439625,0.0003508192,0.0002322043,0.0001691562,0.0001451455,0.0002236139,0.0005785225,0.0002874482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002611858,"about_ca_system_score_gemma":0.000180676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248277,"about_ca_topic_score_gemma":0.001050275,"domain_scores_codex":[0.9998046,0.00004594078,0.00002631393,0.00002481742,0.00005844323,0.0000399217],"domain_scores_gemma":[0.9999353,0.00001192521,0.00001739981,0.00001068513,0.00000766004,0.00001704772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002529788,0.0001053538,0.0002701016,0.00005700484,0.00002008302,0.00003987383,0.00001403378,0.00009078499,0.9952058,0.00005013164,0.00007060026,0.003823248],"study_design_scores_gemma":[0.00005772622,0.001654045,0.006540481,0.00000613866,0.00004973232,0.0002502606,0.00001218146,0.001097545,0.988165,0.00002506474,0.002137617,0.000004242295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934757,0.002737056,0.001606071,0.00007682162,0.00002864344,0.00005801599,0.000292182,0.0001995261,0.001526025],"genre_scores_gemma":[0.9940798,0.001819727,0.002029625,0.00003716294,0.00001387903,0.0000611537,0.0005163159,0.00001492519,0.001427529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009001936,"threshold_uncertainty_score":0.003011405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02399587091114377,"score_gpt":0.2787192228027464,"score_spread":0.2547233518916026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}