{"id":"W2162225483","doi":"10.1002/cncr.24864","title":"Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America","year":2010,"lang":"en","type":"article","venue":"Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McGill University Health Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Sorafenib; Renal cell carcinoma; Rash; Internal medicine; Population; Adverse effect; Expanded access; Surgery; Oncology; Bevacizumab; Kidney cancer; Hepatocellular carcinoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000594907,0.0001609348,0.0003132168,0.00005746039,0.00004339345,0.00001181377,0.0001619604,0.00006090416,0.0000352688],"category_scores_gemma":[0.00005243667,0.0001010441,0.00007413015,0.000360419,0.0001910822,0.00006310363,0.00009633091,0.0002970912,0.000001766405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008776567,"about_ca_system_score_gemma":0.0001948264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004863984,"about_ca_topic_score_gemma":0.001788017,"domain_scores_codex":[0.9988765,0.00003519577,0.0003204464,0.0003152187,0.0002130317,0.0002396819],"domain_scores_gemma":[0.9990886,0.00006537544,0.0001717664,0.000475074,0.00008251736,0.000116648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006913521,0.0007951281,0.5563031,0.0002099472,0.0000455781,0.0000778243,0.001907536,0.0002258078,0.05494975,0.000004976255,0.0003538931,0.3782129],"study_design_scores_gemma":[0.007311094,0.000316929,0.9250233,0.00004922907,0.00006167169,0.000006343765,0.00004603038,0.0000592509,0.05958793,0.000003083011,0.00743369,0.0001014329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950696,0.0005522319,0.000001613517,0.0004813387,0.00016327,0.001093795,0.00004314308,0.00002240481,0.0025726],"genre_scores_gemma":[0.99875,0.0001243098,0.0003173931,0.00009404237,0.00007935379,0.0001195721,0.00002717957,0.0000192667,0.0004689201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3781115,"threshold_uncertainty_score":0.4120459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903789165889219,"score_gpt":0.3025669710936259,"score_spread":0.2835290794347337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}