{"id":"W2162229008","doi":"10.1136/jnnp.2007.128728","title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","year":2007,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":812,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Movement Disorders","funders":"National Institute of Neurological Disorders and Stroke; Hereditary Disease Foundation; National Institutes of Health; Cure Huntington's Disease Initiative; Roy J. Carver Charitable Trust; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Huntington's disease; Disease; Neuroimaging; Medicine; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001786163,0.0004319412,0.0004943346,0.0002969656,0.0004174626,0.0005686198,0.0004588473,0.0006010939,0.001169334],"category_scores_gemma":[0.004225163,0.0003525441,0.000383651,0.0004137633,0.0002530536,0.0005697593,0.0006071349,0.0008344555,0.0002470498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838983,"about_ca_system_score_gemma":0.0003018939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002640854,"about_ca_topic_score_gemma":0.003637305,"domain_scores_codex":[0.9995198,0.000238464,0.00003559013,0.0001347103,0.00004125906,0.00003016235],"domain_scores_gemma":[0.9972134,0.001014784,0.000990337,0.0003701576,0.0001375206,0.0002737637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001687108,0.00008065801,0.9956204,0.00001450188,0.0001594809,0.00007935172,0.00008661283,0.0002037922,0.0001719551,0.00005531144,0.0001169105,0.001723832],"study_design_scores_gemma":[0.0001362598,0.00079138,0.9970637,0.00001525747,0.0001750807,0.0003594115,0.0000961889,0.0006521617,0.0001898929,0.0001107667,0.0004021022,0.00000787127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981105,0.00021228,0.0002969452,0.0000388551,0.000005369989,0.00001924318,0.0009837159,0.000005124441,0.0003280236],"genre_scores_gemma":[0.9979868,0.0001146312,0.0003587317,0.00003191187,0.00001424554,0.00002783222,0.001199843,0.000003384685,0.0002625471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002640854,"threshold_uncertainty_score":0.009446204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628312546467445,"score_gpt":0.2723356917751127,"score_spread":0.2560525663104382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}