{"id":"W2162239011","doi":"10.1016/j.bbamcr.2007.10.015","title":"S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2","year":2007,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; CancerCare Manitoba Foundation; National Institutes of Health; Deutsche Forschungsgemeinschaft; Manitoba Health Research Council","keywords":"Programmed cell death; Cell biology; Apoptosis; Cytochrome c; Rage (emotion); Cytoplasm; Mitochondrion; Cell; Cell culture; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665706,0.0005247649,0.000276473,0.0003213569,0.0001973842,0.000312857,0.0002025687,0.0004655666,0.001244458],"category_scores_gemma":[0.0001016605,0.0001827543,0.0003495802,0.0001332261,0.0002539261,0.0002691988,0.0002344691,0.0008490628,0.0004361807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004046209,"about_ca_system_score_gemma":0.0001362501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002517848,"about_ca_topic_score_gemma":0.0004820902,"domain_scores_codex":[0.9998253,0.00002799353,0.00001263701,0.00002413283,0.00004735621,0.00006268368],"domain_scores_gemma":[0.999898,0.0000170584,0.00002844386,0.00002307632,0.00001096557,0.0000225011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000341635,0.00006421981,0.0002926282,0.00003116611,0.00001411842,0.0002157648,0.0000112943,0.0000390264,0.9970324,0.0001946612,0.00006849882,0.001694669],"study_design_scores_gemma":[0.00008194328,0.00041894,0.008858499,0.00000601304,0.00002221572,0.0008987842,0.00002857406,0.0009185394,0.9872284,0.0001797284,0.001354481,0.000003839958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948901,0.0008892861,0.002130573,0.0001224703,0.00003726406,0.00002818032,0.0002054804,0.0001140479,0.001582573],"genre_scores_gemma":[0.9955204,0.0004457014,0.001033456,0.00004246009,0.00001264857,0.00003568631,0.0002621756,0.00001003663,0.002637453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244458,"threshold_uncertainty_score":0.004163146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431791773546811,"score_gpt":0.3023826575710272,"score_spread":0.2680647398355591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}