{"id":"W2162252625","doi":"10.1128/jvi.02572-12","title":"Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Epitope; Cytotoxic T cell; HLA-B; Virology; Mutant; Human leukocyte antigen; Population; HLA-B Antigens; Reverse transcriptase; Immunology; Antigen; In vitro; Genetics; Gene; Polymerase chain reaction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120347,0.0002150708,0.0002401883,0.0002085742,0.0001168806,0.0003686766,0.0001583328,0.0002514669,0.0007806847],"category_scores_gemma":[0.0003721169,0.0001241099,0.0001850838,0.0001302927,0.0001670386,0.0001346349,0.0003344966,0.0003637534,0.0002448549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001354254,"about_ca_system_score_gemma":0.0001139201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002629747,"about_ca_topic_score_gemma":0.0002227801,"domain_scores_codex":[0.9997575,0.00003275979,0.00002537891,0.00006190567,0.00003847947,0.00008398632],"domain_scores_gemma":[0.9998004,0.00003880043,0.00003109003,0.0000395725,0.00003877095,0.0000514233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003275288,0.00008130832,0.01624654,0.00002630151,0.00001827996,0.0002170405,0.0001774173,0.00007393809,0.9782978,0.0001602082,0.00003339962,0.004340244],"study_design_scores_gemma":[0.0003346139,0.005306001,0.5465522,0.00004820997,0.0002413408,0.01341727,0.001181689,0.004994657,0.4243963,0.0008109166,0.002661547,0.00005520721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991424,0.00008438934,0.0002388596,0.000005417164,0.000003038745,0.00001293211,0.00002016134,0.000007674066,0.0004849799],"genre_scores_gemma":[0.9993581,0.00003383408,0.0002128345,0.00002838771,0.000003175032,0.0000129358,0.00007610534,0.000003513676,0.0002710887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007806847,"threshold_uncertainty_score":0.002611637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00880985607373605,"score_gpt":0.2384957235699645,"score_spread":0.2296858674962284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}