{"id":"W2162267457","doi":"10.1128/jb.00967-13","title":"Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion <i>In Vitro</i> Does Not Always Correlate with Attenuation of Virulence","year":2013,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; ESAT-6; Virulence; Phenotype; Mycobacterium tuberculosis; Microbiology; Secretion; Mycobacterium; Tuberculosis; Mutant; In vitro; Genetics; Bacterial protein; Bacteria; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345261,0.0001976968,0.001242007,0.0003789,0.00002404173,0.000005643428,0.0001320908,0.0002409656,0.0001709761],"category_scores_gemma":[0.0007458138,0.0001234937,0.0001280595,0.0001776142,0.0003598267,0.0002658703,0.00006691005,0.0004302087,0.000003698831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006712753,"about_ca_system_score_gemma":0.0001177213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002064952,"about_ca_topic_score_gemma":0.00001623513,"domain_scores_codex":[0.997398,0.0004892392,0.001260915,0.0002336535,0.0002663635,0.0003517987],"domain_scores_gemma":[0.9971365,0.0005301862,0.001343343,0.0002440942,0.0005790585,0.0001667885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003722913,0.0001132377,0.1563983,0.0003464872,0.0001571309,0.00001618268,0.000249007,0.00001137947,0.8370646,0.00001688658,0.00002419127,0.001879716],"study_design_scores_gemma":[0.001770678,0.00185744,0.6476217,0.0005500948,0.0001201239,0.0003681192,0.0002238267,0.0003855478,0.3467828,0.0002106146,0.00001166724,0.00009738506],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971781,0.0002426855,0.0001752099,0.0017465,0.0001296948,0.0004204457,0.00003601324,0.000004581013,0.00006680429],"genre_scores_gemma":[0.9960232,0.0009631948,0.00266554,0.000195419,0.00007818057,0.00001083783,0.00001981977,0.00001844638,0.00002531904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4912234,"threshold_uncertainty_score":0.5035926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634294343028574,"score_gpt":0.2654789401273505,"score_spread":0.2491359966970647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}