{"id":"W2162267457","doi":"10.1128/jb.00967-13","title":"Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion <i>In Vitro</i> Does Not Always Correlate with Attenuation of Virulence","year":2013,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; ESAT-6; Virulence; Phenotype; Mycobacterium tuberculosis; Microbiology; Secretion; Mycobacterium; Tuberculosis; Mutant; In vitro; Genetics; Bacterial protein; Bacteria; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425331,0.0002575119,0.0002930421,0.0001834775,0.000106834,0.0002782121,0.0001512239,0.000347335,0.0004668418],"category_scores_gemma":[0.0002525886,0.0001196533,0.0002693728,0.0001765691,0.0001599789,0.0001453036,0.0001541885,0.0003752627,0.000329445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823929,"about_ca_system_score_gemma":0.0001193732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006118113,"about_ca_topic_score_gemma":0.000551582,"domain_scores_codex":[0.9998041,0.00002488801,0.00002772555,0.00003795667,0.00005877662,0.00004658494],"domain_scores_gemma":[0.9997932,0.00005199606,0.00005469294,0.00002818255,0.00002759844,0.00004422108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004803625,0.00002100344,0.0007045079,0.000007921753,0.000002598829,0.00004631061,0.000009318328,0.00004008159,0.9986842,0.00001306769,0.000009470254,0.0004135011],"study_design_scores_gemma":[0.000006868609,0.0004601842,0.03164946,0.000005816341,0.00001844401,0.000637734,0.00006999117,0.001167192,0.965485,0.00002413367,0.0004694486,0.000005724895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984029,0.0001706137,0.0008330881,0.00002327419,0.000004744326,0.000009714247,0.0002528107,0.000021781,0.0002809768],"genre_scores_gemma":[0.9976571,0.0001236611,0.001081402,0.00002668948,0.000003400008,0.00001546008,0.0005051531,0.0000147089,0.0005723563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006118113,"threshold_uncertainty_score":0.001561761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634294343028574,"score_gpt":0.2654789401273505,"score_spread":0.2491359966970647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}