{"id":"W2162278249","doi":"10.1038/mtna.2014.19","title":"Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Oncolytic virus; Vesicular stomatitis virus; Virology; Virus; Antibody; Antibody-dependent enhancement; Infectivity; Biology; Neutralizing antibody; Aptamer; Virus quantification; Polyclonal antibodies; Immune system; Vesicular Stomatitis; Viral replication; Molecular biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004266602,0.0003110644,0.0003429279,0.0001173837,0.0001169016,0.00003758923,0.0004315354,0.000247908,0.0001140488],"category_scores_gemma":[0.00007494844,0.0003011013,0.0002347846,0.000238592,0.0002390768,0.000009581345,0.00009625556,0.0002036857,0.00004876663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003156745,"about_ca_system_score_gemma":0.00007423466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334019,"about_ca_topic_score_gemma":0.0000783996,"domain_scores_codex":[0.9978263,0.0004265475,0.0003748199,0.0005772884,0.0003682471,0.0004268185],"domain_scores_gemma":[0.9987051,0.00001944159,0.0001475787,0.0008381372,0.0001703903,0.0001193111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001886516,0.0001289357,0.0003688887,0.0000150464,0.0002260574,0.000003862613,0.0001544002,0.0002046877,0.9644001,0.00002753009,0.00005874992,0.0325252],"study_design_scores_gemma":[0.001534127,0.003536721,0.001479081,0.00002476198,0.00001603161,0.000003453076,0.000051045,0.0004948911,0.9799905,0.0003795839,0.0121722,0.000317599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898411,0.0017774,0.007000303,0.000177283,0.0001136522,0.0005359504,0.00003867989,0.00005165196,0.0004639477],"genre_scores_gemma":[0.9977542,0.0005811132,0.0007144891,0.0004608598,0.0001210079,0.00005552022,0.00009787683,0.00008213912,0.0001328628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0322076,"threshold_uncertainty_score":0.9999441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081581563977763,"score_gpt":0.2795643735549617,"score_spread":0.258748557915184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}