{"id":"W2162278249","doi":"10.1038/mtna.2014.19","title":"Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Oncolytic virus; Vesicular stomatitis virus; Virology; Virus; Antibody; Antibody-dependent enhancement; Infectivity; Biology; Neutralizing antibody; Aptamer; Virus quantification; Polyclonal antibodies; Immune system; Vesicular Stomatitis; Viral replication; Molecular biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028013,0.0004000796,0.0002628584,0.0002052755,0.0001111679,0.0003002254,0.0002419722,0.0004061504,0.0005087509],"category_scores_gemma":[0.0002670519,0.0001654231,0.0001795143,0.0001197523,0.0002134951,0.0002206047,0.0001879682,0.0004045212,0.0001986193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977117,"about_ca_system_score_gemma":0.0001980554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173311,"about_ca_topic_score_gemma":0.0004383186,"domain_scores_codex":[0.9997723,0.00004981877,0.00001525476,0.00005952078,0.00006086491,0.00004222165],"domain_scores_gemma":[0.9998907,0.00003731418,0.00002731443,0.00001213953,0.00001944447,0.00001306856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001749272,0.000008047338,0.00002067387,0.000009139994,0.000002074788,0.00001015819,0.00001022823,0.0001150276,0.9989679,0.00008374003,0.000008274253,0.0007472385],"study_design_scores_gemma":[0.000004239152,0.0000537034,0.0001109509,9.058391e-7,0.000002574851,0.00004209443,0.00000178184,0.0006995245,0.998618,0.00001898128,0.0004452229,0.000001856971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615487,0.00116278,0.03547904,0.000078866,0.00003482053,0.00008276846,0.00008851824,0.0001677348,0.001356727],"genre_scores_gemma":[0.9767885,0.0005883211,0.02002683,0.00007657414,0.00001231128,0.00006242389,0.0001223461,0.00003124684,0.002291355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005087509,"threshold_uncertainty_score":0.002160072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081581563977763,"score_gpt":0.2795643735549617,"score_spread":0.258748557915184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}