{"id":"W2162308737","doi":"10.1016/j.jnutbio.2005.05.014","title":"Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events","year":2005,"lang":"en","type":"article","venue":"The Journal of Nutritional Biochemistry","topic":"Phytochemicals and Antioxidant Activities","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Marine Biosciences; University of Prince Edward Island","funders":"","keywords":"DU145; Matrix metalloproteinase; Vaccinium; Protein kinase A; MAPK/ERK pathway; Chemistry; Angiogenesis; Kinase; Matrix metalloproteinase inhibitor; Cell biology; Biochemistry; Cancer research; Cancer cell; Biology; Cancer; LNCaP; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003612438,0.000285682,0.000545117,0.0001186868,0.0001019257,0.00002028441,0.0001292834,0.0002024063,0.0000549439],"category_scores_gemma":[0.00009027893,0.0002272272,0.000178173,0.000207112,0.0001570887,0.0002700211,0.00004938444,0.0004484727,6.497934e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882995,"about_ca_system_score_gemma":0.0002237154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427203,"about_ca_topic_score_gemma":0.00001001914,"domain_scores_codex":[0.9983021,0.00007715945,0.0006352756,0.0002459632,0.0004435937,0.0002959252],"domain_scores_gemma":[0.9985487,0.00009702037,0.000686191,0.0001749707,0.0003339206,0.0001591852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004059821,0.001297301,0.0001740815,0.0006888774,0.0001503397,0.00001097185,0.00009818247,0.000006143316,0.9926943,0.000001908832,0.0005895281,0.0002286127],"study_design_scores_gemma":[0.0058434,0.0002853085,0.0007410122,0.002555386,0.0001361462,0.00002298718,0.0001766775,0.00003813768,0.9894635,0.0004298411,0.00008294413,0.0002246778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929692,0.003067015,0.00001826548,0.001480511,0.00002260338,0.00116124,0.0012554,0.00001443545,0.00001139047],"genre_scores_gemma":[0.9982024,0.0001803941,0.0005738895,0.00004614478,0.0003773203,0.0001499798,0.0001892641,0.00003273493,0.0002478591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005233273,"threshold_uncertainty_score":0.9266057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008874982440986546,"score_gpt":0.264507760179166,"score_spread":0.2556327777381794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}