{"id":"W2162308737","doi":"10.1016/j.jnutbio.2005.05.014","title":"Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events","year":2005,"lang":"en","type":"article","venue":"The Journal of Nutritional Biochemistry","topic":"Phytochemicals and Antioxidant Activities","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Marine Biosciences; University of Prince Edward Island","funders":"","keywords":"DU145; Matrix metalloproteinase; Vaccinium; Protein kinase A; MAPK/ERK pathway; Chemistry; Angiogenesis; Kinase; Matrix metalloproteinase inhibitor; Cell biology; Biochemistry; Cancer research; Cancer cell; Biology; Cancer; LNCaP; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396212,0.0003684424,0.0002917372,0.0002297903,0.0002165612,0.0002089441,0.0001772104,0.0001845296,0.001424081],"category_scores_gemma":[0.00009301607,0.0001697027,0.0002911562,0.0001698573,0.0001573863,0.0001620979,0.0001384463,0.0004766454,0.0002542138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227672,"about_ca_system_score_gemma":0.0002047135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581949,"about_ca_topic_score_gemma":0.002833916,"domain_scores_codex":[0.9998991,0.00002309544,0.000008100484,0.00001463988,0.00001611453,0.0000389421],"domain_scores_gemma":[0.999934,0.00002195943,0.00001094702,0.000009521178,0.000009261126,0.00001429481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626672,0.00006704024,0.0001346412,0.00004818588,0.000006056676,0.00003273134,0.00001808553,0.00001665026,0.9981855,0.00003822946,0.000048458,0.001141842],"study_design_scores_gemma":[0.00005728157,0.0006002404,0.007715167,0.000004883376,0.00002363437,0.0001577452,0.00002982779,0.0003263894,0.9896416,0.00002554661,0.001414075,0.000003650288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992519,0.004841127,0.001113156,0.0001359244,0.00004596025,0.00003195067,0.0002973443,0.00004643655,0.0009690803],"genre_scores_gemma":[0.9938681,0.001844507,0.001193632,0.0000413637,0.0000180727,0.00004173227,0.0007397317,0.000008324371,0.002244577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581949,"threshold_uncertainty_score":0.00476402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008874982440986546,"score_gpt":0.264507760179166,"score_spread":0.2556327777381794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}