{"id":"W2162327900","doi":"10.1016/s1470-2045(13)70037-8","title":"Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukaemia (OPAL): a randomised open-label phase 2 study","year":2013,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Refractory (planetary science); Internal medicine; Clinical endpoint; Dosing; Regimen; Intention-to-treat analysis; Surgery; Complete remission; Clinical trial; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00171833,0.0003132378,0.001590607,0.000229835,0.0001259383,0.00004394217,0.0008576416,0.0001659643,0.0003005881],"category_scores_gemma":[0.0004434974,0.0001712609,0.0000443846,0.0006339638,0.0003634758,0.0002907152,0.0003822015,0.001061726,0.00006917176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009298897,"about_ca_system_score_gemma":0.001240987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001468355,"about_ca_topic_score_gemma":0.0006292034,"domain_scores_codex":[0.9963766,0.001059303,0.0007403754,0.0005150963,0.0005180181,0.0007905895],"domain_scores_gemma":[0.996751,0.001149667,0.0004413366,0.001099395,0.0003615849,0.0001970762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7016032,0.02475355,0.04760155,0.0002302087,0.002161633,0.001725074,0.01571073,0.00001506234,0.05803694,0.0001087247,0.03010306,0.1179503],"study_design_scores_gemma":[0.9228147,0.04247655,0.02449878,0.0002287161,0.0004643646,0.00008639365,0.002254012,0.0003443207,0.001009365,0.00008740021,0.005389598,0.0003457913],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845771,0.00006187783,0.00001795789,0.003076591,0.0001096481,0.00767021,0.0000209868,0.00004802729,0.00441756],"genre_scores_gemma":[0.9932418,0.0001027008,0.002483857,0.001366013,0.00017062,0.0007308029,0.00005989025,0.00006573927,0.001778589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2212115,"threshold_uncertainty_score":0.6983817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05924214384470794,"score_gpt":0.3954304370345984,"score_spread":0.3361882931898905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}