{"id":"W2162327900","doi":"10.1016/s1470-2045(13)70037-8","title":"Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukaemia (OPAL): a randomised open-label phase 2 study","year":2013,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Refractory (planetary science); Internal medicine; Clinical endpoint; Dosing; Regimen; Intention-to-treat analysis; Surgery; Complete remission; Clinical trial; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345486,0.001973819,0.004169337,0.0007127934,0.0004457722,0.001484843,0.001094291,0.002311236,0.007550889],"category_scores_gemma":[0.002302756,0.0009658861,0.002014963,0.0004874146,0.001501022,0.002143941,0.0006577559,0.003737436,0.001199213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00083228,"about_ca_system_score_gemma":0.0009158699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044608,"about_ca_topic_score_gemma":0.001712999,"domain_scores_codex":[0.9992974,0.0003322222,0.00004085984,0.0001294492,0.00004533719,0.0001546519],"domain_scores_gemma":[0.9987263,0.0003582885,0.0002055802,0.000134237,0.00005318894,0.0005223727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9813249,0.007752597,0.0003299342,0.000169183,0.0003216628,0.00002594532,0.00006079032,0.0002277735,0.001108854,0.00006050767,0.0002219177,0.00839598],"study_design_scores_gemma":[0.907783,0.08997045,0.001217891,0.000011286,0.000169912,0.00002031563,0.00003224863,0.0002143316,0.0001519221,0.00008998941,0.0003198553,0.00001887562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953182,0.001205335,0.0003532753,0.0002906002,0.0002946941,0.001165193,0.0005403723,0.00006053645,0.0007716694],"genre_scores_gemma":[0.9894957,0.001690101,0.001196833,0.0008454742,0.0004619752,0.002552193,0.0008759575,0.00003031215,0.002851632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007550889,"threshold_uncertainty_score":0.02526027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05924214384470794,"score_gpt":0.3954304370345984,"score_spread":0.3361882931898905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}