{"id":"W2162339522","doi":"10.1200/jco.2007.10.9298","title":"Topotecan Is Active Against Wilms’ Tumor: Results of a Multi-Institutional Phase II Study","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Medicine; Topotecan; Wilms' tumor; Wilms tumour; Oncology; Internal medicine; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002605833,0.0001345509,0.0006684051,0.00008016892,0.00007893352,0.000002965145,0.0002533071,0.0003545273,0.00001117666],"category_scores_gemma":[0.001416201,0.0000919212,0.0004294625,0.0001093629,0.0003234629,0.00000795258,0.00009854741,0.0006040047,0.000002372019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005968898,"about_ca_system_score_gemma":0.001238803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002088524,"about_ca_topic_score_gemma":0.00007871055,"domain_scores_codex":[0.9971207,0.0001917599,0.001997385,0.000224895,0.000260072,0.0002051487],"domain_scores_gemma":[0.9972897,0.0001798847,0.001671493,0.0001747923,0.0004453508,0.0002388329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0559,0.02289656,0.002713396,0.00002200517,0.002199828,0.001619903,0.0007984394,0.000654711,0.1356498,0.00002688754,0.00743316,0.7700853],"study_design_scores_gemma":[0.1167094,0.1899627,0.03351158,0.0001532005,0.0006181324,0.000635666,0.002667036,0.0002425975,0.1842189,0.0001103475,0.47055,0.0006203994],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945014,0.0003165515,0.0004698947,0.0005608613,0.001035057,0.0001519296,0.00002814967,0.000002324065,0.002933849],"genre_scores_gemma":[0.9963966,0.0003396244,0.00104179,0.001057387,0.0008535643,0.000001115688,0.000007412559,0.000008261889,0.0002942485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.769465,"threshold_uncertainty_score":0.3748437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07067044566039024,"score_gpt":0.4580025696717894,"score_spread":0.3873321240113992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}