{"id":"W2162339522","doi":"10.1200/jco.2007.10.9298","title":"Topotecan Is Active Against Wilms’ Tumor: Results of a Multi-Institutional Phase II Study","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Medicine; Topotecan; Wilms' tumor; Wilms tumour; Oncology; Internal medicine; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026363,0.0007560232,0.001114492,0.0001957275,0.0003165594,0.0007464649,0.0004924402,0.000512732,0.001173417],"category_scores_gemma":[0.001082082,0.0002393019,0.0005771795,0.0003343446,0.0005832793,0.0005100936,0.0001885641,0.001525347,0.000284042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006848204,"about_ca_system_score_gemma":0.000945079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166714,"about_ca_topic_score_gemma":0.001514063,"domain_scores_codex":[0.9991332,0.0004990404,0.00005236408,0.00009101314,0.0001423891,0.00008202326],"domain_scores_gemma":[0.998795,0.0002931159,0.0002512098,0.0001203464,0.00008220337,0.0004581033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2724288,0.06191681,0.1363603,0.001471378,0.005103086,0.001590621,0.0008550796,0.006156773,0.2465939,0.000314472,0.005732684,0.261476],"study_design_scores_gemma":[0.1103347,0.6210573,0.2191885,0.00006876056,0.001774422,0.003187131,0.0002148518,0.002669616,0.03468488,0.0001119483,0.006644154,0.00006376772],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970535,0.001291048,0.0004366247,0.00009241449,0.00001754568,0.0003071123,0.0002885454,0.00003227498,0.0004808736],"genre_scores_gemma":[0.9956259,0.0009647547,0.0009596339,0.0002081511,0.00005633053,0.0002557999,0.001494374,0.00001539572,0.0004196703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0026363,"threshold_uncertainty_score":0.01394224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07067044566039024,"score_gpt":0.4580025696717894,"score_spread":0.3873321240113992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}