{"id":"W2162386351","doi":"10.2174/187231210792928297","title":"Comparative Efflux of Saquinavir, Ritonavir and Lopinavir from Primary Human Cells","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Statistics Canada","funders":"Ontario HIV Treatment Network; Abbott Laboratories","keywords":"Saquinavir; Ritonavir; Lopinavir; Pharmacology; Efflux; Chemistry; Drug; Peripheral blood mononuclear cell; Protease inhibitor (pharmacology); Virology; Biology; Biochemistry; Viral load; In vitro; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001711425,0.0003184035,0.0008625766,0.0001623538,0.0001123595,0.00002402046,0.0001380434,0.00008573252,0.0001648883],"category_scores_gemma":[0.000007937896,0.000264599,0.0001290796,0.0001604953,0.0003137598,0.0001366136,0.00008795609,0.0003981091,0.00008397127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002875252,"about_ca_system_score_gemma":0.00005223956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001747216,"about_ca_topic_score_gemma":0.00002995341,"domain_scores_codex":[0.9984166,0.00007401432,0.0004104567,0.0004285616,0.0003684197,0.0003019507],"domain_scores_gemma":[0.9990591,0.0001246594,0.0001620268,0.0004040158,0.00005758377,0.0001926141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007112052,0.0002760081,0.01471818,0.00006017639,0.0003094766,0.00005035026,0.004187836,5.948418e-7,0.9668605,0.000275767,0.01156744,0.001622581],"study_design_scores_gemma":[0.004432693,0.0000254178,0.4269473,0.0001062447,0.0005778798,0.00001434926,0.0002344263,0.000007112828,0.4917457,0.0001292652,0.07538477,0.0003949169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928419,0.0005277867,0.00002460407,0.003644529,0.0004761035,0.00051872,0.00006333279,0.00005802496,0.001845017],"genre_scores_gemma":[0.9878168,0.00004979663,0.007764242,0.00162847,0.000336499,0.00003927611,0.0002694611,0.0000336677,0.002061757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4751148,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003694436337104,"score_gpt":0.2564478154845611,"score_spread":0.24641087112119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}