{"id":"W2162386351","doi":"10.2174/187231210792928297","title":"Comparative Efflux of Saquinavir, Ritonavir and Lopinavir from Primary Human Cells","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Statistics Canada","funders":"Ontario HIV Treatment Network; Abbott Laboratories","keywords":"Saquinavir; Ritonavir; Lopinavir; Pharmacology; Efflux; Chemistry; Drug; Peripheral blood mononuclear cell; Protease inhibitor (pharmacology); Virology; Biology; Biochemistry; Viral load; In vitro; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975451,0.0002631169,0.0004625969,0.0001457326,0.0001839327,0.0005207763,0.0001793452,0.0002496818,0.002040582],"category_scores_gemma":[0.0002919587,0.0001404725,0.0002512191,0.0002159564,0.000166219,0.0002216783,0.0001798696,0.0005298662,0.0008613741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416107,"about_ca_system_score_gemma":0.0001704656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008521184,"about_ca_topic_score_gemma":0.001079731,"domain_scores_codex":[0.9996877,0.00008538704,0.00003833076,0.00006714811,0.00007552776,0.00004592919],"domain_scores_gemma":[0.9997604,0.0001062885,0.00002205385,0.00003630331,0.00006080032,0.00001407708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002931497,0.00002665804,0.0004502356,0.00005148695,0.000009350947,0.00005783651,0.00005946911,0.00006418271,0.9969543,0.00004560264,0.00005755924,0.001930126],"study_design_scores_gemma":[0.00001876181,0.0006992643,0.008301078,0.00001150117,0.00002258714,0.0004034165,0.00005378858,0.000634373,0.987525,0.00003540966,0.002286244,0.000008625539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719263,0.008215366,0.01411781,0.0001387057,0.00007279272,0.00008851614,0.001611917,0.0001473549,0.003681328],"genre_scores_gemma":[0.9737017,0.003087562,0.01222967,0.0001031742,0.00003074729,0.0001633552,0.003495374,0.00005015059,0.007138174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040582,"threshold_uncertainty_score":0.00682646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003694436337104,"score_gpt":0.2564478154845611,"score_spread":0.24641087112119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}