{"id":"W2162410375","doi":"10.1093/infdis/jis502","title":"Modest Nonadherence to Antiretroviral Therapy Promotes Residual HIV-1 Replication in the Absence of Virological Rebound in Plasma","year":2012,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Viral load; Viral replication; Medicine; Antiretroviral therapy; Immunology; Lentivirus; Internal medicine; Human immunodeficiency virus (HIV); Virology; RNA; Reverse transcriptase; Virus; Viral disease; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004505831,0.0001720484,0.0002723851,0.0002090511,0.0001453895,0.0003680598,0.000121001,0.0002017465,0.001083086],"category_scores_gemma":[0.001379951,0.0001524109,0.0001909877,0.0001559458,0.0002362996,0.0001567025,0.000276076,0.000485989,0.0001552082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295525,"about_ca_system_score_gemma":0.0001421499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003523561,"about_ca_topic_score_gemma":0.0004352618,"domain_scores_codex":[0.9997602,0.00006378224,0.00002318895,0.00003738332,0.00007194679,0.00004335879],"domain_scores_gemma":[0.9987729,0.0003280151,0.0005521552,0.00009651492,0.00008305401,0.0001672467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003211014,0.000528458,0.6776454,0.0001682516,0.0001228001,0.0005793906,0.0003507218,0.0005499126,0.2848533,0.0002052188,0.0001809373,0.03160453],"study_design_scores_gemma":[0.00004633928,0.002789514,0.9754928,0.00001823189,0.00006184822,0.0008629385,0.0000716714,0.0009000799,0.01918458,0.00007539058,0.0004898225,0.000006853934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993165,0.0002395683,0.0001307489,0.00001255332,0.00000151514,0.000006481132,0.0000258733,0.000005743575,0.0002610222],"genre_scores_gemma":[0.9995514,0.00006823045,0.0002093017,0.00001425704,0.000005071277,0.000005501931,0.00005568993,0.000001472023,0.00008899166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083086,"threshold_uncertainty_score":0.003623247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471662755886568,"score_gpt":0.2946561989772646,"score_spread":0.2699395714183989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}