{"id":"W2162417913","doi":"10.1128/aac.01172-07","title":"Cidofovir and (<i>S</i>)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cidofovir; Biology; DNA polymerase; Polymerase; DNA; Vaccinia; Processivity; Primer (cosmetics); Virus; Virology; Molecular biology; Biochemistry; Chemistry; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306789,0.00046885,0.0004961686,0.0002920275,0.0001354922,0.0004351112,0.0003111167,0.0005735026,0.001012822],"category_scores_gemma":[0.0003600882,0.0001924988,0.0002705653,0.0002210492,0.0002254049,0.0002298019,0.0002175214,0.0004861669,0.0004713507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379621,"about_ca_system_score_gemma":0.0002927272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000445409,"about_ca_topic_score_gemma":0.0004517858,"domain_scores_codex":[0.9997163,0.00005020507,0.00003046544,0.00007171026,0.00008267997,0.00004845929],"domain_scores_gemma":[0.9997845,0.00005351848,0.00007222174,0.00001432268,0.00001583422,0.00005961405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000408246,0.00003268265,0.0004708188,0.0001794381,0.00001832969,0.0001051499,0.00001442991,0.0003108939,0.9854929,0.0005181601,0.0001657213,0.01228324],"study_design_scores_gemma":[0.00004812735,0.0006718239,0.001792212,0.000008190897,0.00001903457,0.0007454903,0.00001135654,0.0007041339,0.9825382,0.0001293785,0.01331739,0.00001461703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.903133,0.05788246,0.02696368,0.0002387942,0.0002879263,0.0002529876,0.001598357,0.0004856715,0.009157145],"genre_scores_gemma":[0.9713428,0.006423058,0.01743467,0.0001485652,0.00004632799,0.0001045282,0.001412923,0.00003474372,0.003052319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012822,"threshold_uncertainty_score":0.003388286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007263185316929808,"score_gpt":0.2519167337521087,"score_spread":0.2446535484351788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}